PD 184352 | Tocris Bioscience 4237 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 184352

catalog :

4237

quantity :

10 mg (also 50 mg)

price :

267 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Wang Y, Zhu L, Kuokkanen S, Pollard J. Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17β is mediated by a PKC-ERK1/2-mTOR signaling pathway. Proc Natl Acad Sci U S A. 2015;112:E1382-91 pubmed publisher
Martin E, Krebs A, Burks H, Elliott S, Baddoo M, Collins Burow B, et al. miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line leads to enhanced mitogen activated protein kinase signaling. Genes Cancer. 2014;5:353-64 pubmed
Wouters E, Hudson C, McArdle C, Bernal A. Central role for protein kinase C in oxytocin and epidermal growth factor stimulated cyclooxygenase 2 expression in human myometrial cells. BMC Res Notes. 2014;7:357 pubmed publisher

product information

brand :

Tocris

master code :

4237

SKU :

4237/10

product name :

PD 184352

description :

Selective MEK inhibitor

target :

MEK Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

478.66

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective MEK inhibitor (Ki = 300 nM in vitro ). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo . Orally active.

catalog number base :

4237

product keywords :

pfizer mek1 mek2 mkk1 mkk2 inhibitors inhibits selective mapk signaling signalling map kinases PD184352 CI1040 CI-1040 MEK 4237,

extended description :

Selective MEK inhibitor

chemical name text :

2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide

formula :

C 17 H 14 ClF 2 IN 2 O 2

formula text :

C17H14ClF2IN2O2

cas num :

212631-79-3

2020 USD :

259

2021 USD :

267 USD

alt names :

CI-1040

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage