A 839977 | Tocris Bioscience 4232 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 839977

catalog :

4232

quantity :

10 mg (also 50 mg)

price :

217 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Gangadharan V, Nohe A, Caplan J, Czymmek K, Duncan R. Caveolin-1 regulates P2X7 receptor signaling in osteoblasts. Am J Physiol Cell Physiol. 2015;308:C41-50 pubmed publisher

product information

brand :

Tocris

master code :

4232

SKU :

4232/10

product name :

A 839977

description :

Potent P2X7 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

413.26

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent P2X7 antagonist; blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively). Displays antinociceptive effects in rat and mice models of inflammatory pain. CNS penetrant.

catalog number base :

4232

product keywords :

A839977 purinergics purinoceptors purines p2x7 antagonists antinociceptive cns penetrant P2X Receptors 4232,

extended description :

Potent P2X7 antagonist

chemical name text :

1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-1H-tetrazol-5-amine

formula :

C 19 H 14 Cl 2 N 6 O

formula text :

C19H14Cl2N6O

cas num :

870061-27-1

2020 USD :

212

2021 USD :

217 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage