A 839977 | Tocris Bioscience 4232/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 839977

catalog :

4232/10

quantity :

10 mg (also 50 mg)

price :

269 USD

citations: 2

Reference
Shao X, Guha S, Lu W, Campagno K, Beckel J, Mills J, et al. Polarized Cytokine Release Triggered by P2X7 Receptor from Retinal Pigmented Epithelial Cells Dependent on Calcium Influx. Cells. 2020;9: pubmed publisher
Gangadharan V, Nohe A, Caplan J, Czymmek K, Duncan R. Caveolin-1 regulates P2X7 receptor signaling in osteoblasts. Am J Physiol Cell Physiol. 2015;308:C41-50 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4232

SKU :

4232/10

product name :

A 839977

Description :

Potent P2X7 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

413.26

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A 839977 is a potent P2X7 antagonist; blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively). Displays antinociceptive effects in rat and mice models of inflammatory pain. CNS penetrant.

extended description :

Potent P2X7 antagonist

chemical name text :

1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-1H-tetrazol-5-amine

formula :

C 19 H 14 Cl 2 N 6 O

formula text :

C19H14Cl2N6O

cas num :

870061-27-1

USD :

269 USD

product details :

Potent P2X7 antagonist

storage :

Store at +4°C