C 646 | Tocris Bioscience 4200/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

C 646

catalog :

4200/10

quantity :

10 mg (also 50 mg)

price :

314 USD

citations: 2

Reference
Wang W, Thomas R, Oh J, Su D. Accumulation of pTreg cells is detrimental in late-onset (aged) mouse model of multiple sclerosis. Aging Cell. 2022;21:e13630 pubmed publisher
Kim B, Luo Y, Zhan X, Zhang Z, Shi X, Yi J, et al. Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation. Cell Rep. 2021;36:109357 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4200

SKU :

4200/10

product name :

C 646

Description :

p300/CBP inhibitor

target :

Other Transferase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

445.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

C 646 is a p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines. Also represses pluripotency markers in mouse embryonic stem cells. Newer p300 probes are also available: iP300w (Cat. No. 7270) and A 485 (Cat. No. 6387). . This compound is a mixture of Z:E isomers (~ 80:20).

extended description :

p300/CBP inhibitor

chemical name text :

4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid

formula :

C 24 H 19 N 3 O 6

formula text :

C24H19N3O6

cas num :

328968-36-1

USD :

314 USD

product details :

p300/CBP inhibitor

storage :

Store at +4°C