IEM 1925 dihydrobromide | Tocris Bioscience 4198/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IEM 1925 dihydrobromide

catalog :

4198/10

quantity :

10 mg (also 50 mg)

price :

225 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Zhang D, Lape R, Shaikh S, Kohegyi B, Watson J, Cais O, et al. Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics. Nat Commun. 2023;14:1659 pubmed publisher
Zhang D, Watson J, Matthews P, Cais O, Greger I. Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature. 2021;594:454-458 pubmed publisher

product information

brand :

Tocris

MasterCode :

4198

SKU :

4198/10

product name :

IEM 1925 dihydrobromide

target :

AMPA Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

95%

observed molecular weight :

422.24

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

IEM 1925 dihydrobromide is a voltage- and use-dependent open-channel antagonist of AMPA receptors. Selective between subtypes; blocks GluA2 subunit-lacking receptors more potently than GluA2-containing receptors (KD for GluA2-containing AMPAR is 210 times higher at -80 mV). More potent than IEM 1460 (Cat. No. 1636) and IEM 1754 due to a slower unblocking rate. Alleviates inflammatory pain in a rat model of peripheral inflammation.

extended description :

Voltage- and use-dependent open-channel AMPA blocker

chemical name text :

N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide

formula :

C 17 H 28 N 2 .2HBr

formula text :

C17H28N2.2HBr

cas num :

258282-23-4

USD :

225 USD

product details :

Voltage- and use-dependent open-channel AMPA blocker

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage