product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
VPC 23019
catalog :
4195/10
quantity :
10 mg
price :
437 USD
more info or order :
citations: 8
Reference
Nagata Y, Miyagawa K, Ohata Y, Petrusca D, Pagnotti G, Mohammad K, et al. Increased S1P expression in osteoclasts enhances bone formation in an animal model of Paget's disease. J Cell Biochem. 2021;122:335-348 pubmed publisher
Del Gaudio I, Hendrix S, Christoffersen C, Wadsack C. Neonatal HDL Counteracts Placental Vascular Inflammation via S1P-S1PR1 Axis. Int J Mol Sci. 2020;21: pubmed publisher
Del Gaudio I, Sreckovic I, Zardoya Laguardia P, Bernhart E, Christoffersen C, Frank S, et al. Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature. Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865:158632 pubmed publisher
Greig F, Nather K, Ballantyne M, Kazi Z, Alganga H, Ewart M, et al. Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse. Eur J Pharmacol. 2019;842:1-9 pubmed publisher
Sharma A, Zhang Y, Buikema J, Serpooshan V, Chirikian O, Kosaric N, et al. Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation. Sci Rep. 2018;8:6618 pubmed publisher
Gibson A, Xu J, Lively C. Within-population covariation between sexual reproduction and susceptibility to local parasites. Evolution. 2016;70:2049-60 pubmed publisher
Willems L, Zahn N, Ferreirós N, Scholich K, Maggio N, Deller T, et al. Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy. Acta Neuropathol Commun. 2016;4:28 pubmed publisher
Miller A, Alvarez S, Spiegel S, Lebman D. Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol Cell Biol. 2008;28:4142-51 pubmed publisher
product information
brand :
Tocris
MasterCode :
4195
SKU :
4195/10
product name :
VPC 23019
target :
Sphingosine-1-phosphate Receptor Antagonists
category :
Small Molecules
unit size :
10 mg
purity :
95%
observed molecular weight :
372.4
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
VPC 23019 is a sphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).
extended description :
S1P1 and S1P3 antagonist
chemical name text :
2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide
formula :
C 17 H 29 N 2 O 5 P
formula text :
C17H29N2O5P
cas num :
449173-19-7
USD :
437 USD
product details :
S1P1 and S1P3 antagonist
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK