CP 100356 hydrochloride | Tocris Bioscience 4193/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CP 100356 hydrochloride

catalog :

4193/10

quantity :

10 mg (also 50 mg)

price :

268 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Sheehy R, Kuder C, Bachman Z, Hohl R. Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil. Cancer Biol Ther. 2015;16:1259-68 pubmed publisher

product information

brand :

Tocris

MasterCode :

4193

SKU :

4193/10

product name :

CP 100356 hydrochloride

target :

Multidrug Transporter Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

597.1

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CP 100356 hydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Ki values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms). Inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC50 = 0.5 M) and prazosin transport in BCRP-transfected MDCKII cells (IC50 = 1.5 M). Displays weak or no inhibitory activity against MRP1, OATP1B1 and several major human P450 enzymes (IC50 50 M).

extended description :

P-gp inhibitor

chemical name text :

4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-2[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine hydrochloride

formula :

C 31 H 36 N 4 O 6 .HCl

formula text :

C31H36N4O6.HCl

cas num :

142715-48-8

USD :

268 USD

product details :

P-gp inhibitor

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage