product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PD 0325901
catalog :
4192
quantity :
10 mg (also 50 mg)
price :
276 USD
more info or order :
citations: 22
Reference
Canizo J, Ynsaurralde Rivolta A, Vázquez Echegaray C, Suvá M, Alberio V, Aller J, et al. A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos. BMC Dev Biol. 2019;19:13 pubmed publisher
Zhang S, Chen T, Chen N, Gao D, Shi B, Kong S, et al. Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells. Nat Commun. 2019;10:496 pubmed publisher
Tuck A, Natarajan K, Rice G, Borawski J, Mohn F, Rankova A, et al. Distinctive features of lincRNA gene expression suggest widespread RNA-independent functions. Life Sci Alliance. 2018;1:e201800124 pubmed publisher
Wang C, Najm R, Xu Q, Jeong D, Walker D, Balestra M, et al. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018;24:647-657 pubmed publisher
Caires Júnior L, Goulart E, Melo U, Araujo B, Alvizi L, Soares Schanoski A, et al. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun. 2018;9:475 pubmed publisher
Liu P, Chen M, Liu Y, Qi L, Ding S. CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. Cell Stem Cell. 2018;22:252-261.e4 pubmed publisher
Yang J, Ryan D, Wang W, Tsang J, Lan G, Masaki H, et al. Establishment of mouse expanded potential stem cells. Nature. 2017;550:393-397 pubmed publisher
Stumpf P, Smith R, Lenz M, Schuppert A, Muller F, Babtie A, et al. Stem Cell Differentiation as a Non-Markov Stochastic Process. Cell Syst. 2017;5:268-282.e7 pubmed publisher
Gupta A, Anjomani Virmouni S, Koundouros N, Dimitriadi M, Choo Wing R, Valle A, et al. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Mol Cell. 2017;65:999-1013.e7 pubmed publisher
Jullien J, Vodnala M, Pasque V, Oikawa M, Miyamoto K, Allen G, et al. Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways. Mol Cell. 2017;65:873-884.e8 pubmed publisher
El Zawily A, Toosi B, Freywald T, Indukuri V, Vizeacoumar F, Leary S, et al. The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation. Oncotarget. 2016;7:77865-77877 pubmed publisher
de Oliveira A, Yousif N, Bhatia H, Hermanek J, Huell M, Fiebich B. Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia. J Neuroinflammation. 2016;13:11 pubmed publisher
Sladitschek H, Neveu P. The bimodally expressed microRNA miR-142 gates exit from pluripotency. Mol Syst Biol. 2015;11:850 pubmed publisher
Solari C, Vázquez Echegaray C, Cosentino M, Petrone M, Waisman A, Luzzani C, et al. Manganese Superoxide Dismutase Gene Expression Is Induced by Nanog and Oct4, Essential Pluripotent Stem Cells' Transcription Factors. PLoS ONE. 2015;10:e0144336 pubmed publisher
Maza I, Caspi I, Zviran A, Chomsky E, Rais Y, Viukov S, et al. Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors. Nat Biotechnol. 2015;33:769-74 pubmed publisher
Kearns N, Pham H, Tabak B, Genga R, Silverstein N, Garber M, et al. Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nat Methods. 2015;12:401-403 pubmed publisher
Mattis V, Tom C, Akimov S, Saeedian J, Østergaard M, Southwell A, et al. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Hum Mol Genet. 2015;24:3257-71 pubmed publisher
Holland W, Chinn D, Lara P, Gandara D, Mack P. Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines. J Cancer Res Clin Oncol. 2015;141:615-26 pubmed publisher
Muthusamy T, Mukherjee O, Menon R, Megha P, Panicker M. A method to identify and isolate pluripotent human stem cells and mouse epiblast stem cells using lipid body-associated retinyl ester fluorescence. Stem Cell Reports. 2014;3:169-84 pubmed publisher
Koehler K, Hashino E. 3D mouse embryonic stem cell culture for generating inner ear organoids. Nat Protoc. 2014;9:1229-44 pubmed publisher
Denham M, Bye C, Leung J, Conley B, Thompson L, Dottori M. Glycogen synthase kinase 3? and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage. Stem Cells. 2012;30:2400-11 pubmed publisher
Cho L, Wamaitha S, Tsai I, Artus J, Sherwood R, Pedersen R, et al. Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. Development. 2012;139:2866-77 pubmed publisher
product information
brand :
Tocris
master code :
4192
SKU :
4192/10
product name :
PD 0325901
description :
Potent inhibitor of MEK1/2
target :
MEK Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
482.19
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent MEK1 and MEK2 inhibitor. Inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). Inhibits the growth of melanoma cell lines in vitro and in vivo ; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. Also inhibits production of proangiogenic cytokines such as VEGF. Enhances generation of induced pluripotent stem cells (iPSCs). Orally active.
catalog number base :
4192
product keywords :
pfizer PD0325901 PD325901 mek1 mek2 mkk1 mkk2 mapk signalling signaling selective inhibitors inhibits proapoptotic organoids PD325901 MEK Stem Cell Reprogramming Organoids 4192,
extended description :
Potent inhibitor of MEK1/2
chemical name text :
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
formula :
C 16 H 14 F 3 IN 2 O 4
formula text :
C16H14F3IN2O4
cas num :
391210-10-9
2020 USD :
267
2021 USD :
276 USD
alt names :
PD325901
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK