product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
PD 0325901
catalog :
4192/10
quantity :
10 mg (also 50 mg)
price :
343 USD
more info or order :
citations: 47
Reference
Decourtye Espiard L, Clemessy M, Leneuve P, Mire E, Ledent T, Le Bouc Y, et al. Stimulation of GHRH Neuron Axon Growth by Leptin and Impact of Nutrition during Suckling in Mice. Nutrients. 2023;15: pubmed publisher
Gerdes P, Lim S, Ewing A, Larcombe M, Chan D, Sánchez Luque F, et al. Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells. Nat Commun. 2022;13:7470 pubmed publisher
xc1 vila Gonz xe1 lez D, Portillo W, Barrag xe1 n xc1 lvarez C, Hernández Montes G, Flores Garza E, Molina Hern xe1 ndez A, et al. The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells. elife. 2022;11: pubmed publisher
Mau K, Karimlou D, Barneda D, Brochard V, Royer C, Leeke B, et al. Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development. Nat Commun. 2022;13:3861 pubmed publisher
Zywitza V, Rusha E, Shaposhnikov D, Ruiz Orera J, Telugu N, Rishko V, et al. Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction. Sci Rep. 2022;12:3100 pubmed publisher
Io S, Iemura Y, Takashima Y. Optimized protocol for naive human pluripotent stem cell-derived trophoblast induction. STAR Protoc. 2021;2:100921 pubmed publisher
Zhang B, Li H, Hu Z, Jiang H, Stablewski A, Marzullo B, et al. Generation of mouse-human chimeric embryos. Nat Protoc. 2021;16:3954-3980 pubmed publisher
Lee H, Wang Y, Yang W, Xia W, Wei Y, Chan L, et al. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nat Commun. 2021;12:2788 pubmed publisher
Ferreira A, Casamento A, Carrillo Roas S, Halff E, Panambalana J, Subramaniam S, et al. Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis. Nat Commun. 2021;12:2424 pubmed publisher
Io S, Kabata M, Iemura Y, Semi K, Morone N, Minagawa A, et al. Capturing human trophoblast development with naive pluripotent stem cells in vitro. Cell Stem Cell. 2021;28:1023-1039.e13 pubmed publisher
Yuan W, Yao Z, Veerapandian V, Yang X, Wang X, Chen D, et al. The histone demethylase KDM2B regulates human primordial germ cell-like cells specification. Int J Biol Sci. 2021;17:527-538 pubmed publisher
Pósfai E, Schell J, Janiszewski A, Rovic I, Murray A, BRADSHAW B, et al. Evaluating totipotency using criteria of increasing stringency. Nat Cell Biol. 2021;23:49-60 pubmed publisher
Anlas K, Baillie Benson P, Arat xf3 K, Turner D, Trivedi V. Gastruloids: Embryonic Organoids from Mouse Embryonic Stem Cells to Study Patterning and Development in Early Mammalian Embryos. Methods Mol Biol. 2021;2258:131-147 pubmed publisher
Bergert M, Lembo S, Sharma S, Russo L, Milovanović D, Gretarsson K, et al. Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation. Cell Stem Cell. 2021;28:209-216.e4 pubmed publisher
Kim J, T Jakobsen S, Natarajan K, Won K. TENET: gene network reconstruction using transfer entropy reveals key regulatory factors from single cell transcriptomic data. Nucleic Acids Res. 2021;49:e1 pubmed publisher
Loganathan N, McIlwraith E, Belsham D. Bisphenol A Induces Agrp Gene Expression in Hypothalamic Neurons through a Mechanism Involving ATF3. Neuroendocrinology. 2021;111:678-695 pubmed publisher
Hatzistergos K, Durante M, Valasaki K, Wanschel A, Harbour J, Hare J. A novel cardiomyogenic role for Isl1+ neural crest cells in the inflow tract. Sci Adv. 2020;6: pubmed publisher
Schuster S, Heuten E, Velic A, Admard J, Synofzik M, Ossowski S, et al. CHIP mutations affect the heat shock response differently in human fibroblasts and iPSC-derived neurons. Dis Model Mech. 2020;13: pubmed publisher
Urosevic J, Blasco M, Llorente A, Bellmunt A, Berenguer Llergo A, Guiu M, et al. ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer. Cancer Res. 2020;80:4668-4680 pubmed publisher
Ortmann D, Brown S, Czechanski A, Aydin S, Muraro D, Huang Y, et al. Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation. Cell Stem Cell. 2020;27:470-481.e6 pubmed publisher
Amaral M, Goulart E, Caires Júnior L, Morales Vicente D, Soares Schanoski A, Gomes R, et al. Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins. PLoS Negl Trop Dis. 2020;14:e0008424 pubmed publisher
Otsuka R, Wada H, Tsuji H, Sasaki A, Murata T, Itoh M, et al. Efficient generation of thymic epithelium from induced pluripotent stem cells that prolongs allograft survival. Sci Rep. 2020;10:224 pubmed publisher
Kim M, Zhong Y, Jung K, Chai Y, Binas B. Basal-type lumenogenesis in extraembryonic endoderm stem cells models the early visceral endoderm. J Cell Sci. 2019;132: pubmed publisher
Canizo J, Ynsaurralde Rivolta A, Vázquez Echegaray C, Suvá M, Alberio V, Aller J, et al. A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos. BMC Dev Biol. 2019;19:13 pubmed publisher
Zhang S, Chen T, Chen N, Gao D, Shi B, Kong S, et al. Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells. Nat Commun. 2019;10:496 pubmed publisher
Yang J, Ryan D, Lan G, Zou X, Liu P. In vitro establishment of expanded-potential stem cells from mouse pre-implantation embryos or embryonic stem cells. Nat Protoc. 2019;14:350-378 pubmed publisher
Tuck A, Natarajan K, Rice G, Borawski J, Mohn F, Rankova A, et al. Distinctive features of lincRNA gene expression suggest widespread RNA-independent functions. Life Sci Alliance. 2018;1:e201800124 pubmed publisher
Wang C, Najm R, Xu Q, Jeong D, Walker D, Balestra M, et al. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018;24:647-657 pubmed publisher
Caires Júnior L, Goulart E, Melo U, Araujo B, Alvizi L, Soares Schanoski A, et al. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun. 2018;9:475 pubmed publisher
Liu P, Chen M, Liu Y, Qi L, Ding S. CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. Cell Stem Cell. 2018;22:252-261.e4 pubmed publisher
Yang J, Ryan D, Wang W, Tsang J, Lan G, Masaki H, et al. Establishment of mouse expanded potential stem cells. Nature. 2017;550:393-397 pubmed publisher
Stumpf P, Smith R, Lenz M, Schuppert A, Muller F, Babtie A, et al. Stem Cell Differentiation as a Non-Markov Stochastic Process. Cell Syst. 2017;5:268-282.e7 pubmed publisher
Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169:243-257.e25 pubmed publisher
Gupta A, Anjomani Virmouni S, Koundouros N, Dimitriadi M, Choo Wing R, Valle A, et al. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Mol Cell. 2017;65:999-1013.e7 pubmed publisher
Jullien J, Vodnala M, Pasque V, Oikawa M, Miyamoto K, Allen G, et al. Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways. Mol Cell. 2017;65:873-884.e8 pubmed publisher
El Zawily A, Toosi B, Freywald T, Indukuri V, Vizeacoumar F, Leary S, et al. The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation. Oncotarget. 2016;7:77865-77877 pubmed publisher
de Oliveira A, Yousif N, Bhatia H, Hermanek J, Huell M, Fiebich B. Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia. J Neuroinflammation. 2016;13:11 pubmed publisher
Sladitschek H, Neveu P. The bimodally expressed microRNA miR-142 gates exit from pluripotency. Mol Syst Biol. 2015;11:850 pubmed publisher
Solari C, Vázquez Echegaray C, Cosentino M, Petrone M, Waisman A, Luzzani C, et al. Manganese Superoxide Dismutase Gene Expression Is Induced by Nanog and Oct4, Essential Pluripotent Stem Cells' Transcription Factors. PLoS ONE. 2015;10:e0144336 pubmed publisher
Maza I, Caspi I, Zviran A, Chomsky E, Rais Y, Viukov S, et al. Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors. Nat Biotechnol. 2015;33:769-74 pubmed publisher
Kearns N, Pham H, Tabak B, Genga R, Silverstein N, Garber M, et al. Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nat Methods. 2015;12:401-403 pubmed publisher
Mattis V, Tom C, Akimov S, Saeedian J, Østergaard M, Southwell A, et al. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Hum Mol Genet. 2015;24:3257-71 pubmed publisher
Holland W, Chinn D, Lara P, Gandara D, Mack P. Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines. J Cancer Res Clin Oncol. 2015;141:615-26 pubmed publisher
Muthusamy T, Mukherjee O, Menon R, Megha P, Panicker M. A method to identify and isolate pluripotent human stem cells and mouse epiblast stem cells using lipid body-associated retinyl ester fluorescence. Stem Cell Reports. 2014;3:169-84 pubmed publisher
Koehler K, Hashino E. 3D mouse embryonic stem cell culture for generating inner ear organoids. Nat Protoc. 2014;9:1229-44 pubmed publisher
Denham M, Bye C, Leung J, Conley B, Thompson L, Dottori M. Glycogen synthase kinase 3? and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage. Stem Cells. 2012;30:2400-11 pubmed publisher
Cho L, Wamaitha S, Tsai I, Artus J, Sherwood R, Pedersen R, et al. Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. Development. 2012;139:2866-77 pubmed publisher
product information
brand :
Tocris
MasterCode :
4192
SKU :
4192/10
product name :
PD 0325901
target :
MEK Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
482.19
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
PD 0325901 is a potent MEK1 and MEK2 inhibitor. PD 0325901 inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). PD 0325901 inhibits the growth of melanoma cell lines in vitro and in vivo ; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. PD 0325901 also inhibits production of proangiogenic cytokines such as VEGF. PD 0325901 enhances generation of induced pluripotent stem cells (iPSCs). PD 0325901 in combination with Vitamin C sustains mouse ES cells at an undifferentiated and hypomethylated state. PD 0325901 promotes myelin recovery in drug-induced demyelination in vivo in mice model. Orally active. . For more information about how PD 0325901 may be used, see our protocols: Culturing Transcriptomically Distinct Pluripotent mESCs, Highly Efficient Generation of CiPSCs from MEFs, Accelerated Induction of Cortical Neurons from hiPSCs .
extended description :
Potent inhibitor of MEK1/2
chemical name text :
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
formula :
C 16 H 14 F 3 IN 2 O 4
formula text :
C16H14F3IN2O4
cas num :
391210-10-9
USD :
343 USD
product details :
Potent inhibitor of MEK1/2
alt names :
PD325901
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK