UK 5099 | Tocris Bioscience 4186/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

UK 5099

catalog :

4186/10

quantity :

10 mg (also 50 mg)

price :

214 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Tompkins S, Sheldon R, Rauckhorst A, Noterman M, Solst S, Buchanan J, et al. Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis. Cell Rep. 2019;28:2608-2619.e6 pubmed publisher
Rauckhorst A, Gray L, Sheldon R, Fu X, Pewa A, Feddersen C, et al. The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Mol Metab. 2017;6:1468-1479 pubmed publisher
Kaji I, Iwanaga T, Watanabe M, Guth P, Engel E, Kaunitz J, et al. SCFA transport in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2015;308:G188-97 pubmed publisher

product information

brand :

Tocris

master code :

4186

SKU :

4186/10

rank :

0.061

product name :

UK 5099

description :

MCT inhibitor; also inhibits mitochondrial pyruvate carrier

target :

Monocarboxylate Transporter Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

UK 5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).

extended description :

MCT inhibitor; also inhibits mitochondrial pyruvate carrier

chemical name text :

2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid

formula :

C 18 H 12 N 2 O 2

formula text :

C18H12N2O2

cas num :

56396-35-1

USD :

214 USD

product details :

MCT inhibitor; also inhibits mitochondrial pyruvate carrier

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage