Ro 3306 | Tocris Bioscience 4181 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ro 3306

catalog :

4181

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Smith R, Cordeiro M, Davey N, Vallardi G, Ciliberto A, Gross F, et al. PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore. Cell Rep. 2019;28:2206-2219.e8 pubmed publisher
Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand A, Robertson D, et al. RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Mol Cell. 2019;73:413-428.e7 pubmed publisher
Meyer S, Dunn M, Vidler D, Porter A, Blain P, Jowsey P. Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1. FASEB J. 2019;33:2796-2808 pubmed publisher
Sacristan C, Ahmad M, Keller J, Fermie J, Groenewold V, Tromer E, et al. Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis. Nat Cell Biol. 2018;20:800-810 pubmed publisher
Karki M, Keyhaninejad N, Shuster C. Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay. Nat Commun. 2017;8:15803 pubmed publisher
Ramkumar P, Lee C, Moradian A, Sweredoski M, Hess S, Sharrocks A, et al. JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1. J Biol Chem. 2015;290:29617-28 pubmed publisher
Shukla A, Kong D, Sharma M, Magidson V, Loncarek J. Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation. Nat Commun. 2015;6:8077 pubmed publisher
Silva V, Plooster M, Leung J, Cassimeris L. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Cell Cycle. 2015;14:1070-81 pubmed publisher
Goonesekere N, Wang X, Ludwig L, Guda C. A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS ONE. 2014;9:e93046 pubmed publisher
Rossi M, Duan S, Jeong Y, Horn M, Saraf A, Florens L, et al. Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. Mol Cell. 2013;49:1159-66 pubmed publisher

product information

brand :

Tocris

master code :

4181

SKU :

4181/10

product name :

Ro 3306

description :

Cdk1 inhibitor

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

351.45

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ATP-competitive cyclin-dependent kinase 1 (cdk1) inhibitor (Ki values range from 35 to 240 nM depending on cdk1 binding partner). Also reported to inhibit other cdks (Ki values are 0.89-1.32, 0.03 and >2 M for cdk2, cdk3 and cdk4, respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML).

catalog number base :

4181

product keywords :

Ro3306 inhibits cdk1 cyclin-dependent kinase 1 inhibitors cell cycle arrest apoptotic Cyclin-dependent Kinase 4181,

extended description :

Cdk1 inhibitor

chemical name text :

5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

formula :

C 18 H 13 N 3 OS 2

formula text :

C18H13N3OS2

cas num :

872573-93-8

2020 USD :

218

2021 USD :

227 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage