product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
MDL 100907
catalog :
4173
quantity :
10 mg (also 50 mg)
price :
286 USD
more info or order :
citations: 7
Reference
Zhou W, Jin Y, Meng Q, Zhu X, Bai T, Tian Y, et al. A neural circuit for comorbid depressive symptoms in chronic pain. Nat Neurosci. 2019;22:1649-1658 pubmed publisher
Alharris E, Singh N, Nagarkatti P, Nagarkatti M. Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019;10:45-59 pubmed publisher
Athilingam J, Ben Shalom R, Keeshen C, Sohal V, Bender K. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. elife. 2017;6: pubmed publisher
Moutkine I, Quentin E, Guiard B, Maroteaux L, Doly S. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers. J Biol Chem. 2017;292:6352-6368 pubmed publisher
Grønli J, Clegern W, Schmidt M, Nemri R, Rempe M, Gallitano A, et al. Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT2 Deficits. Sleep. 2016;39:2189-2199 pubmed publisher
Bocchio M, Fucsina G, Oikonomidis L, McHugh S, Bannerman D, Sharp T, et al. Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Neuropsychopharmacology. 2015;40:3015-26 pubmed publisher
Daftary S, Calderon G, Rios M. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience. 2012;224:125-34 pubmed publisher
product information
brand :
Tocris
master code :
4173
SKU :
4173/10
product name :
MDL 100907
description :
Potent and selective 5-HT2A antagonist
target :
5-HT2A Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
373.46
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM). Exhibits > 80-fold selectivity for 5-HT2A over other serotonergic receptor subtypes. Antipsychotic agent in vivo .
catalog number base :
4173
product keywords :
MDL100907 potent selective 5-HT2A receptors antagonists 5HT2A antipsychotic 5-HT2A Receptors 4173,
extended description :
Potent and selective 5-HT2A antagonist
chemical name text :
(R)-(+)- -(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol
formula :
C 22 H 28 FNO 3
formula text :
C22H28FNO3
cas num :
139290-65-6
2020 USD :
272
2021 USD :
286 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK