MDL 100907 | Tocris Bioscience 4173/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MDL 100907

catalog :

4173/10

quantity :

10 mg (also 50 mg)

price :

371 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Vizcarra V, Barber K, Franca Solomon G, Majuta L, Smith A, Langlais P, et al. Targeting 5-HT2A receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model. Neurosci Lett. 2022;789:136864 pubmed publisher
Li L, Zhang L, He Z, Ma H, Zhang Y, Xun Y, et al. Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability. elife. 2021;10: pubmed publisher
Yuede C, Wallace C, Davis T, Gardiner W, Hettinger J, Edwards H, et al. Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer's disease. J Neurochem. 2021;156:658-673 pubmed publisher
Zhou W, Jin Y, Meng Q, Zhu X, Bai T, Tian Y, et al. A neural circuit for comorbid depressive symptoms in chronic pain. Nat Neurosci. 2019;22:1649-1658 pubmed publisher
Sengupta A, Holmes A. A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory. Neuron. 2019;: pubmed publisher
Alharris E, Singh N, Nagarkatti P, Nagarkatti M. Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019;10:45-59 pubmed publisher
Athilingam J, Ben Shalom R, Keeshen C, Sohal V, Bender K. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. elife. 2017;6: pubmed publisher
Moutkine I, Quentin E, Guiard B, Maroteaux L, Doly S. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers. J Biol Chem. 2017;292:6352-6368 pubmed publisher
Grønli J, Clegern W, Schmidt M, Nemri R, Rempe M, Gallitano A, et al. Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT2 Deficits. Sleep. 2016;39:2189-2199 pubmed publisher
Bocchio M, Fucsina G, Oikonomidis L, McHugh S, Bannerman D, Sharp T, et al. Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Neuropsychopharmacology. 2015;40:3015-26 pubmed publisher
Daftary S, Calderon G, Rios M. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience. 2012;224:125-34 pubmed publisher

product information

brand :

Tocris

catalog number base :

4173

SKU :

4173/10

product name :

MDL 100907

units size :

10 mg (also 50 mg)

description :

Potent and selective 5-HT2A antagonist

target :

5-HT2A Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

373.46

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MDL 100907 is a potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM, IC50 = 3.3-5.1 nM). MDL 100907 exhibits > 80-fold selectivity for 5-HT2A receptors over other serotonergic receptor subtypes. MDL 100907 is neuroprotective; protects cultured dopaminergic neurons from MPP+ induced toxicity. Antipsychotic agent in vivo .

top caption :

Potent and selective 5-HT2A antagonist

extended description :

Potent and selective 5-HT2A antagonist

chemical name text :

(R)-(+)- -(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol

formula :

C22H28FNO3

formula text :

C22H28FNO3

cas num :

139290-65-6

USD :

371 USD

product details :

Potent and selective 5-HT2A antagonist

alt names :

Volinanserin

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage