VU 0364739 hydrochloride | Tocris Bioscience 4171/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 0364739 hydrochloride

catalog :

4171/10

quantity :

10 mg (also 50 mg)

price :

318 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Lu W, Chung C, Chen R, Huang L, Lien L, Chang C, et al. An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets. J Clin Med. 2018;7: pubmed publisher
Ngo Thai Bich V, Hongu T, Miura Y, Katagiri N, Ohbayashi N, Yamashita Kanemaru Y, et al. Physiological function of phospholipase D2 in anti-tumor immunity: regulation of CD8+ T lymphocyte proliferation. Sci Rep. 2018;8:6283 pubmed publisher
Krishnan B, Kayed R, Taglialatela G. Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits. Alzheimers Dement (N Y). 2018;4:89-102 pubmed publisher
Liu X, Liu X, Chen D, Jiang X, Ma W. PLD2 regulates microtubule stability and spindle migration in mouse oocytes during meiotic division. Peerj. 2017;5:e3295 pubmed publisher
Chelakkot C, Ghim J, Rajasekaran N, Choi J, Kim J, Jang M, et al. Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin. Sci Rep. 2017;7:1573 pubmed publisher
Jiang Y, Sverdlov M, Toth P, Huang L, Du G, Liu Y, et al. Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells. J Biol Chem. 2016;291:20729-38 pubmed publisher
MartÃnez MartÃnez N, MartÃnez Alonso E, Ballesta J, MartÃnez MenÃ¡rguez J. Phospholipase D2 is involved in the formation of Golgi tubules and ArfGAP1 recruitment. PLoS ONE. 2014;9:e111685 pubmed publisher
Basiouni S, Fuhrmann H, Schumann J. The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells. Int J Mol Sci. 2013;14:9005-17 pubmed publisher

product information

brand :

Tocris

master code :

4171

SKU :

4171/10

rank :

0.061

product name :

VU 0364739 hydrochloride

description :

Potent and selective PLD2 inhibitor

target :

Phospholipase Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

VU 0364739 hydrochloride is a potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).

extended description :

Potent and selective PLD2 inhibitor

chemical name text :

N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide

formula :

C 26 H 27 FN 4 O 2 .HCl

formula text :

C26H27FN4O2.HCl

cas num :

1244640-48-9

USD :

318 USD

product details :

Potent and selective PLD2 inhibitor

storage :

Store the unopened product at room temperature. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage