PIT 1 | Tocris Bioscience 4168 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PIT 1

catalog :

4168

quantity :

10 mg (also 50 mg)

price :

157 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Juvekar A, Hu H, Yadegarynia S, Lyssiotis C, Ullas S, Lien E, et al. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proc Natl Acad Sci U S A. 2016;113:E4338-47 pubmed publisher

product information

brand :

Tocris

master code :

4168

SKU :

4168/10

product name :

PIT 1

description :

PIP3 antagonist. Blocks PIP3-PH interaction; inhibits Akt signaling

target :

Inositol Lipid Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

351.76

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective PIP3 antagonist. Blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03 M). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo .

catalog number base :

4168

product keywords :

PIT1 Supplier Akt signaling inhibitors inhibits blocks PH-PIP3 pleckstrin homology PITenins Inositol Lipids Protein Kinase B/Akt 4168,

extended description :

PIP3 antagonist. Blocks PIP3-PH interaction; inhibits Akt signaling

chemical name text :

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

formula :

C 14 H 10 ClN 3 O 4 S

formula text :

C14H10ClN3O4S

cas num :

53501-41-0

2020 USD :

153

2021 USD :

157 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage