TCN 213 | Tocris Bioscience 4163 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TCN 213

catalog :

4163

quantity :

10 mg (also 50 mg)

price :

193 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Izumi Y, Zorumski C. Sensitivity of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices. J Pharmacol Exp Ther. 2015;352:267-73 pubmed publisher
Prickett T, Zerlanko B, Hill V, Gartner J, Qutob N, Jiang J, et al. Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation. J Invest Dermatol. 2014;134:2390-2398 pubmed publisher
McKay S, Griffiths N, Butters P, Thubron E, Hardingham G, Wyllie D. Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. Br J Pharmacol. 2012;166:924-37 pubmed publisher

product information

brand :

Tocris

master code :

4163

SKU :

4163/10

product name :

TCN 213

description :

NMDA antagonist; selective for GluN2A over GluN2B containing receptors

target :

NMDA Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

376.54

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NMDA receptor antagonist, selective for GluN1/GluN2A (formally NR1/NR2A) (pIC50 = 5.4) over GluN1/GluN2B (formally NR1/NR2B) containing receptors. . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

catalog number base :

4163

product keywords :

TCN213 selective NMDA receptor antagonist NR1/NR2A NR2A-containing NR2B GluN1 GluN2A GluN2B NMDA Receptors 4163,

extended description :

NMDA antagonist; selective for GluN2A over GluN2B containing receptors

chemical name text :

N-(Cyclohexylmethyl)-2-[(5-[(phenylmethyl)amino]-1,3,4-thiadiazol-2-yl}thio]acetamide

formula :

C 18 H 24 N 4 OS 2

formula text :

C18H24N4OS2

cas num :

556803-08-8

2020 USD :

189

2021 USD :

193 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage