TCN 201 | Tocris Bioscience 4154/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TCN 201

catalog :

4154/10

quantity :

10 mg (also 50 mg)

price :

263 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Lassus B, Naudé J, Faure P, Guedin D, von Boxberg Y, Mannoury La Cour C, et al. Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips. Sci Rep. 2018;8:17461 pubmed publisher
Brancaccio M, Patton A, Chesham J, Maywood E, Hastings M. Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron. 2017;93:1420-1435.e5 pubmed publisher
Tian M, Xu J, Lei G, Lombroso P, Jackson M, MacDonald J. STEP activation by G?q coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit. Sci Rep. 2016;6:36684 pubmed publisher
McQuail J, Beas B, Kelly K, Simpson K, Frazier C, Setlow B, et al. NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline. J Neurosci. 2016;36:12537-12548 pubmed
Chen G, Xie R, Gao Y, Xu Z, Zhao L, Bang S, et al. ?-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain. Nat Commun. 2016;7:12531 pubmed publisher
Bu F, Du R, Li Y, Quinn J, Wang M. NR2A contributes to genesis and propagation of cortical spreading depression in rats. Sci Rep. 2016;6:23576 pubmed publisher
Liu H, Li Y, Wang Y, Wang X, An X, Wang S, et al. The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood. Mol Brain. 2015;8:49 pubmed publisher
Gu Q, Yu D, Hu Z, Liu X, Yang Y, Luo Y, et al. miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement. Nat Commun. 2015;6:6789 pubmed publisher
Hu Z, Zhao J, Hu T, Luo Y, Zhu J, Li Z. miR-501-3p mediates the activity-dependent regulation of the expression of AMPA receptor subunit GluA1. J Cell Biol. 2015;208:949-59 pubmed publisher
Izumi Y, Zorumski C. Sensitivity of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices. J Pharmacol Exp Ther. 2015;352:267-73 pubmed publisher
Jia J, Zhao J, Hu Z, Lindberg D, Li Z. Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci. 2013;16:1627-36 pubmed publisher

product information

brand :

Tocris

master code :

4154

SKU :

4154/10

rank :

0.061

product name :

TCN 201

description :

GluN1/GluN2A-selective NMDA antagonist

target :

NMDA Receptor Antagonists

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TCN 201 is a NMDA receptor antagonist selective for GluN1/GluN2A (formally NR1/NR2A) over GluN1/GluN2B (formally NR1/NR2B) containing receptors (pIC50 values are 6.8 and 4.3, respectively, in human recombinant GluN1/GluN2A (formally NR1/NR2A) and GluN1/GluN2B (formally NR1/NR2B) FLIPR/Ca2+ assays). . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

extended description :

GluN1/GluN2A-selective NMDA antagonist

chemical name text :

3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide

formula :

C 21 H 17 ClFN 3 O 4 S

formula text :

C21H17ClFN3O4S

cas num :

852918-02-6

USD :

263 USD

product details :

GluN1/GluN2A-selective NMDA antagonist

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage