GSK 690693 | Tocris Bioscience 4144 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 690693

catalog :

4144

quantity :

10 mg

price :

331 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Rogers S, Gahring L. Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways. PLoS ONE. 2015;10:e0143319 pubmed publisher
Sokołowska P, Urbańska A, Biegańska K, Wagner W, Ciszewski W, Namiecinska M, et al. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. J Mol Neurosci. 2014;52:48-55 pubmed publisher
Khuituan P, Teerapornpuntakit J, Wongdee K, Suntornsaratoon P, Konthapakdee N, Sangsaksri J, et al. Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D?-enhanced duodenal calcium transport in male mice. Am J Physiol Endocrinol Metab. 2012;302:E903-13 pubmed publisher

product information

brand :

Tocris

master code :

4144

SKU :

4144/10

product name :

GSK 690693

description :

Akt kinase inhibitor. Antitumor

target :

Akt (Protein Kinase B) Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

425.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

catalog number base :

4144

product keywords :

GSK 690693 inhibits Akt inhibitors GSK690693 antitumor antiproliferative Akt (Protein Kinase B) Protein Kinase B/Akt 4144,

extended description :

Akt kinase inhibitor. Antitumor

chemical name text :

4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

formula :

C 21 H 27 N 7 O 3

formula text :

C21H27N7O3

cas num :

937174-76-0

2020 USD :

318

2021 USD :

331 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage