GSK 2334470 | Tocris Bioscience 4143 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 2334470

catalog :

4143

quantity :

10 mg (also 50 mg)

price :

257 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Heberle A, Razquin Navas P, Langelaar Makkinje M, Kasack K, Sadik A, Faessler E, et al. The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner. Life Sci Alliance. 2019;2: pubmed publisher
Xing T, Hass D, Zhang S, Barnstable C. The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development. Front Cell Dev Biol. 2018;6:134 pubmed publisher
Qi L, Toyoda H, Xu D, Zhou Y, Sakurai N, Amano K, et al. PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells. Cancer Cell Int. 2015;15:91 pubmed publisher
Busada J, Chappell V, Niedenberger B, Kaye E, Keiper B, Hogarth C, et al. Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse. Dev Biol. 2015;397:140-9 pubmed publisher
Al Ejeh F, Miranda M, Shi W, Simpson P, Song S, Vargas A, et al. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget. 2014;5:3145-58 pubmed

product information

brand :

Tocris

master code :

4143

SKU :

4143/10

product name :

GSK 2334470

description :

Highly potent, selective PDPK1 (PDK1) inhibitor

target :

PDK-1 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

462.59

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent 3-phosphoinositide-dependent protein kinase (PDPK1) inhibitor (IC50 ~ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro ; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in BrafV600E::Pten(-/-) mice.

catalog number base :

4143

product keywords :

GSK2334470 PDK1 S6K p70 ribosomal SGK serum glucocorticoid protein kinases inhibits inhibitors Akt 3-phosphoinositide-dependent selective PDPK1 Phosphoinositide-dependent Kinase 1 PDK1 4143,

extended description :

Highly potent, selective PDPK1 (PDK1) inhibitor

chemical name text :

(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide

formula :

C 25 H 34 N 8 O

formula text :

C25H34N8O

cas num :

1227911-45-6

2020 USD :

249

2021 USD :

257 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage