EB 47 | Tocris Bioscience 4140 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

EB 47

catalog :

4140

quantity :

10 mg (also 50 mg)

price :

265 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Rom S, Zuluaga Ramirez V, Reichenbach N, Dykstra H, Gajghate S, Pacher P, et al. PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier. J Neuroinflammation. 2016;13:254 pubmed
Rom S, Reichenbach N, Dykstra H, Persidsky Y. The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity. Front Microbiol. 2015;6:878 pubmed publisher
Rom S, Zuluaga Ramirez V, Dykstra H, Reichenbach N, Ramirez S, Persidsky Y. Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions. J Cereb Blood Flow Metab. 2015;35:28-36 pubmed publisher

product information

brand :

Tocris

master code :

4140

SKU :

4140/10

product name :

EB 47

description :

Potent PARP-1 inhibitor

target :

Poly(ADP-ribose) Polymerase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

610.45

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of PARP-1 (IC50 = 45 nM). Reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model.

catalog number base :

4140

product keywords :

EB47 PARP-1 poly(ADP-ribose) polymerase-1 inhibitors inhibits PARP1 Poly(ADP-ribose) Polymerase 4140,

extended description :

Potent PARP-1 inhibitor

chemical name text :

5 -Deoxy-5 -[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5 -oxoadenosine dihydrochloride

formula :

C 24 H 27 N 9 O 6 .2HCl

formula text :

C24H27N9O6.2HCl

cas num :

1190332-25-2

2020 USD :

257

2021 USD :

265 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage