EB 47 | Tocris Bioscience 4140/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

EB 47

catalog :

4140/10

quantity :

10 mg (also 50 mg)

price :

307 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Rom S, Zuluaga Ramirez V, Reichenbach N, Dykstra H, Gajghate S, Pacher P, et al. PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier. J Neuroinflammation. 2016;13:254 pubmed
Rom S, Reichenbach N, Dykstra H, Persidsky Y. The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity. Front Microbiol. 2015;6:878 pubmed publisher
Rom S, Zuluaga Ramirez V, Dykstra H, Reichenbach N, Ramirez S, Persidsky Y. Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions. J Cereb Blood Flow Metab. 2015;35:28-36 pubmed publisher

image

image 1 :

Cat.No. 4140 - EB 47 C24H27N9O6.2HCl CAS No. 1190332-25-2

product information

brand :

Tocris

master code :

4140

SKU :

4140/10

rank :

0.061

product name :

EB 47

description :

Potent PARP-1 inhibitor

target :

Poly(ADP-ribose) Polymerase Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

EB 47 is a potent inhibitor of PARP-1 (IC50 = 45 nM). Reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model.

extended description :

Potent PARP-1 inhibitor

chemical name text :

5 -Deoxy-5 -[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5 -oxoadenosine dihydrochloride

formula :

C 24 H 27 N 9 O 6 .2HCl

formula text :

C24H27N9O6.2HCl

cas num :

1190332-25-2

USD :

307 USD

product details :

Potent PARP-1 inhibitor

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage