product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
U 73343
catalog :
4133
quantity :
10 mg (also 50 mg)
price :
162 USD
more info or order :
citations: 13
Reference
Babola T, Kersbergen C, Wang H, Bergles D. Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. elife. 2020;9: pubmed publisher
Atakpa P, Thillaiappan N, Mataragka S, Prole D, Taylor C. IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes. Cell Rep. 2018;25:3180-3193.e7 pubmed publisher
Rajan A, Housden B, Wirtz Peitz F, Holderbaum L, Perrimon N. A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion. Dev Cell. 2017;43:83-98.e6 pubmed publisher
Osman S, Taylor K, Allcock N, Rainbow R, Mahaut Smith M. Detachment of surface membrane invagination systems by cationic amphiphilic drugs. Sci Rep. 2016;6:18536 pubmed publisher
Yoon J, Jeong S, Hong J. The Effect of Therapeutic Blockades of Dust Particles-Induced Ca²⁺ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells. Mediators Inflamm. 2015;2015:843024 pubmed publisher
Montalbano A, Corradetti R, Mlinar B. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PLoS ONE. 2015;10:e0140369 pubmed publisher
Tabatadze N, Huang G, May R, Jain A, Woolley C. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci. 2015;35:11252-65 pubmed publisher
Rioult Pedotti M, Pekanovic A, Atiemo C, Marshall J, Luft A. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. PLoS ONE. 2015;10:e0124986 pubmed publisher
Kubota H, Nagao S, Obata K, Hirono M. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS ONE. 2014;9:e106316 pubmed publisher
Brenner D, Golden J, Vogt S, Dhaka A, Story G, Gereau R. A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Pain. 2014;155:2124-33 pubmed publisher
Zhao L, Levine E. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 2014;111:1008-15 pubmed publisher
Ruisanchez E, Dancs P, Kerék M, Nemeth T, Farago B, Balogh A, et al. Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase. FASEB J. 2014;28:880-90 pubmed publisher
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach Mansky R, Sacks D, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492:123-7 pubmed publisher
product information
brand :
Tocris
master code :
4133
SKU :
4133/10
product name :
U 73343
description :
Analog of U 73122 (Cat. No. 1268)
target :
Phospholipase Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
466.66
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Analog of U 73122 ; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTP S-induced Ca2+ influx in hepatocytes. . Active Analog also available.
catalog number base :
4133
product keywords :
U73343 negative control analog U73122 plc phospholipases c Phospholipases Phospholipase C 4133,
extended description :
Analog of U 73122 (Cat. No. 1268)
chemical name text :
1-[6-[[(17 )-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
formula :
C 29 H 42 N 2 O 3
formula text :
C29H42N2O3
cas num :
142878-12-4
2020 USD :
155
2021 USD :
162 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK