product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
U 73343
catalog :
4133/10
quantity :
10 mg (also 50 mg)
price :
209 USD
more info or order :
citations: 22
Reference
Oubraim S, Shen R, Haj Dahmane S. Oxytocin excites dorsal raphe serotonin neurons and bidirectionally gates their glutamate synapses. iScience. 2023;26:106707 pubmed publisher
Al Fahad D, Alyaseen F, Al Amery A, Ibeas Bin C. Regulation of Focal Adhesion Dynamics and Cell Migration by PLC/PI3K-Mediated Metabolism of PtdIns (4,5) P2 in a Breast Cancer Cell Line. Rep Biochem Mol Biol. 2022;11:270-281 pubmed publisher
Fulgenzi G, Hong Z, Tomassoni Ardori F, Barella L, Becker J, Barrick C, et al. Novel metabolic role for BDNF in pancreatic β-cell insulin secretion. Nat Commun. 2020;11:1950 pubmed publisher
Babola T, Kersbergen C, Wang H, Bergles D. Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. elife. 2020;9: pubmed publisher
Oh Y, Lai J, Mills H, Erdjument Bromage H, Giammarinaro B, Saadipour K, et al. A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila. Nature. 2019;574:559-564 pubmed publisher
Nagai J, Rajbhandari A, Gangwani M, Hachisuka A, Coppola G, Masmanidis S, et al. Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue. Cell. 2019;177:1280-1292.e20 pubmed publisher
Atakpa P, Thillaiappan N, Mataragka S, Prole D, Taylor C. IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes. Cell Rep. 2018;25:3180-3193.e7 pubmed publisher
Rajan A, Housden B, Wirtz Peitz F, Holderbaum L, Perrimon N. A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion. Dev Cell. 2017;43:83-98.e6 pubmed publisher
Lee D, Ji M, Kang J, Kyung S, Hong J. Dust particles-induced intracellular Ca2+ signaling and reactive oxygen species in lung fibroblast cell line MRC5. Korean J Physiol Pharmacol. 2017;21:327-334 pubmed publisher
Shutov L, Warwick C, Shi X, Gnanasekaran A, Shepherd A, Mohapatra D, et al. The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1. J Neurosci. 2016;36:5055-70 pubmed publisher
Osman S, Taylor K, Allcock N, Rainbow R, Mahaut Smith M. Detachment of surface membrane invagination systems by cationic amphiphilic drugs. Sci Rep. 2016;6:18536 pubmed publisher
Yoon J, Jeong S, Hong J. The Effect of Therapeutic Blockades of Dust Particles-Induced Ca²⁺ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells. Mediators Inflamm. 2015;2015:843024 pubmed publisher
Montalbano A, Corradetti R, Mlinar B. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PLoS ONE. 2015;10:e0140369 pubmed publisher
Tabatadze N, Huang G, May R, Jain A, Woolley C. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci. 2015;35:11252-65 pubmed publisher
Rioult Pedotti M, Pekanovic A, Atiemo C, Marshall J, Luft A. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. PLoS ONE. 2015;10:e0124986 pubmed publisher
Kubota H, Nagao S, Obata K, Hirono M. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS ONE. 2014;9:e106316 pubmed publisher
Brenner D, Golden J, Vogt S, Dhaka A, Story G, Gereau R. A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Pain. 2014;155:2124-33 pubmed publisher
Zhao L, Levine E. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 2014;111:1008-15 pubmed publisher
Ruisanchez E, Dancs P, Kerék M, Nemeth T, Farago B, Balogh A, et al. Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase. FASEB J. 2014;28:880-90 pubmed publisher
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach Mansky R, Sacks D, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492:123-7 pubmed publisher
Fung C, Jones S, Ntrakwah A, Naseem K, Farndale R, Mahaut Smith M. Platelet Ca(2+) responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: roles for secondary activation of P2X1 receptors and release from intracellular Ca(2+) stores. Blood. 2012;119:3613-21 pubmed publisher
Mandal M, Yan Z. Phosphatidylinositol (4,5)-bisphosphate regulation of N-methyl-D-aspartate receptor channels in cortical neurons. Mol Pharmacol. 2009;76:1349-59 pubmed publisher
image
image 1 :
Tocris Bioscience 4133/10 image 1
Cat.No. 4133 - U 73343 C29H42N2O3 CAS No. 142878-12-4
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
4133
SKU :
4133/10
product name :
U 73343
description :
Analog of U 73122 (Cat. No. 1268)
target :
Phospholipase Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at RT
observed molecular weight :
466.66
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
U 73343 is an analog of U 73122 ; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTP S-induced Ca2+ influx in hepatocytes. . Active Analog also available.
product keywords :
U73343 negative control analog U73122 plc phospholipases c Phospholipases Phospholipase C 4133,
extended description :
Analog of U 73122 (Cat. No. 1268)
chemical name text :
1-[6-[[(17 )-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
formula :
C29H42N2O3
formula text :
C29H42N2O3
cas num :
142878-12-4
USD :
202
USD 2025 :
209 USD
product details :
Analog of U 73122 (Cat. No. 1268)
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK