XMD 8-92 | Tocris Bioscience 4132 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

XMD 8-92

catalog :

4132

quantity :

10 mg (also 50 mg)

price :

264 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Thompson J, Shukla A, Leggett A, Munson P, Miller J, Macpherson M, et al. Extracellular signal regulated kinase 5 and inflammasome in progression of mesothelioma. Oncotarget. 2018;9:293-305 pubmed publisher
Pereira D, Simões A, Gomes S, Castro R, Carvalho T, Rodrigues C, et al. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Oncotarget. 2016;7:34322-40 pubmed publisher
SimÃµes A, Pereira D, Gomes S, Brito H, Carvalho T, French A, et al. Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-ÎºB activation. Cell Death Dis. 2015;6:e1718 pubmed publisher
Al Ejeh F, Miranda M, Shi W, Simpson P, Song S, Vargas A, et al. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget. 2014;5:3145-58 pubmed

product information

brand :

Tocris

master code :

4132

SKU :

4132/10

product name :

XMD 8-92

description :

ERK5/BMK1 inhibitor; also BRD4 inhibitor

target :

ERK Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

474.55

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ERK5 (BMK1) and BRD4 inhibitor (Kd values are 80 and 190 nM, respectively). Also inhibits DCAMKL2, PLK4 and TNK1 (Kd values are 190, 600 and 890 nM). Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. Also reduces BMK1-dependent transactivating activity of MEF2C. Inhibits proliferation in a variety of cancer cell lines; blocks tumor cell proliferation and tumor-associated angiogenesis.

catalog number base :

4132

product keywords :

erk5 bmk1 big MAP kinase 1 inhibitors inhibits antitumor antiproliferative antiproliferation XMD8-92 bromodomains BRD4 ERK Bromodomains 4132,

extended description :

ERK5/BMK1 inhibitor; also BRD4 inhibitor

chemical name text :

2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

formula :

C 26 H 30 N 6 O 3

formula text :

C26H30N6O3

cas num :

1234480-50-2

2020 USD :

253

2021 USD :

264 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage