XMD 8-92 | Tocris Bioscience 4132/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

XMD 8-92

catalog :

4132/10

quantity :

10 mg (also 50 mg)

price :

306 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Thompson J, Shukla A, Leggett A, Munson P, Miller J, Macpherson M, et al. Extracellular signal regulated kinase 5 and inflammasome in progression of mesothelioma. Oncotarget. 2018;9:293-305 pubmed publisher
Pereira D, Simões A, Gomes S, Castro R, Carvalho T, Rodrigues C, et al. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Oncotarget. 2016;7:34322-40 pubmed publisher
SimÃµes A, Pereira D, Gomes S, Brito H, Carvalho T, French A, et al. Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-ÎºB activation. Cell Death Dis. 2015;6:e1718 pubmed publisher
Al Ejeh F, Miranda M, Shi W, Simpson P, Song S, Vargas A, et al. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget. 2014;5:3145-58 pubmed

image

image 1 :

Cat.No. 4132 - XMD 8-92 C26H30N6O3 CAS No. 1234480-50-2

product information

brand :

Tocris

master code :

4132

SKU :

4132/10

rank :

0.061

product name :

XMD 8-92

description :

ERK5/BMK1 inhibitor; also BRD4 inhibitor

target :

ERK Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

XMD 8-92 is an ERK5 (BMK1) and BRD4 inhibitor (Kd values are 80 and 190 nM, respectively). Also inhibits DCAMKL2, PLK4 and TNK1 (Kd values are 190, 600 and 890 nM). Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. Also reduces BMK1-dependent transactivating activity of MEF2C. Inhibits proliferation in a variety of cancer cell lines; blocks tumor cell proliferation and tumor-associated angiogenesis.

extended description :

ERK5/BMK1 inhibitor; also BRD4 inhibitor

chemical name text :

2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

formula :

C 26 H 30 N 6 O 3

formula text :

C26H30N6O3

cas num :

1234480-50-2

USD :

306 USD

product details :

ERK5/BMK1 inhibitor; also BRD4 inhibitor

storage :

Store the unopened product at room temperature. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage