Bisindolylmaleimide II | Tocris Bioscience 4128 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Bisindolylmaleimide II

catalog :

4128

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
O Neill N, Sylantyev S. Feature Article: Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C. Exp Biol Med (Maywood). 2018;243:1046-1055 pubmed publisher
Jones M, Craik J, Gibbins J, Poole A. Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus. J Biol Chem. 2004;279:40475-83 pubmed

product information

brand :

Tocris

master code :

4128

SKU :

4128/10

product name :

Bisindolylmaleimide II

description :

Potent PKC inhibitor; also potent nAChR antagonist

target :

Protein Kinase C Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

438.52

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 0.01 M). Displays selectivity for PKC over protein kinase A (PKA) and phosphorylase kinase (PK) (IC50 values are 0.75 and 2 M for PK and PKA respectively). Also displays potent, noncompetitive antagonism at nicotinic cholinergic receptors (IC50 ~ 0.03 M for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells).

catalog number base :

4128

product keywords :

protein kinase C PKC inhibits inhibitors nicotinic cholinergic acetylcholine nAChRs antagonists antagonism catecholamines potent Protein Kinase C Nicotinic Receptors (Non-selective) 4128,

extended description :

Potent PKC inhibitor; also potent nAChR antagonist

chemical name text :

3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione

formula :

C 27 H 26 N 4 O 2

formula text :

C27H26N4O2

cas num :

137592-45-1

2020 USD :

207

2021 USD :

216 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage