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product summary
company name :
Tocris Bioscience
product type :
chemical
product name :
DMH-1
catalog :
4126/10
quantity :
10 mg (also 50 mg)
price :
299 USD
citations: 58
Reference
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Lyons D, Perry K, Batzel G, Henry J. BMP signaling plays a role in anterior-neural/head development, but not organizer activity, in the gastropod Crepidula fornicata. Dev Biol. 2020;463:135-157 pubmed publisher
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Mehler V, Burns C, Stauss H, Francis R, Moore M. Human iPSC-Derived Neural Crest Stem Cells Exhibit Low Immunogenicity. Mol Ther Methods Clin Dev. 2020;16:161-171 pubmed publisher
Kim B, Jeong Y, Wong M, Martin L. DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations. Acta Neuropathol Commun. 2020;8:7 pubmed publisher
Sato T, Higashioka K, Sakurai H, Yamamoto T, Goshima N, Ueno M, et al. Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells. Stem Cell Reports. 2019;13:352-365 pubmed publisher
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Bai L, Chang H, Zhu Y, Leung P. Bone morphogenetic protein 2 increases lysyl oxidase activity via up-regulation of snail in human granulosa-lutein cells. Cell Signal. 2019;53:201-211 pubmed publisher
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Li X, Tao Y, Bradley R, Du Z, Tao Y, Kong L, et al. Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells. Stem Cell Reports. 2018;11:998-1008 pubmed publisher
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Wu Y, Chang H, Huang H, Sheng J, Leung P. Bone morphogenetic protein 2 regulates cell-cell communication by down-regulating connexin43 expression in luteinized human granulosa cells. Mol Hum Reprod. 2017;23:155-165 pubmed publisher
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Varas A, Valencia J, Lavocat F, Martínez V, Thiam N, Hidalgo L, et al. Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes. Arthritis Res Ther. 2015;17:192 pubmed publisher
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Du Z, Chen H, Liu H, Lu J, Qian K, Huang C, et al. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun. 2015;6:6626 pubmed publisher
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product information
brand :
Tocris
master code :
4126
SKU :
4126/10
product name :
DMH-1
unit size :
10 mg (also 50 mg)
seo description :
Selective ALK2 inhibitor
target :
BMP and Other Activin Receptor Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
380.44
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
DMH-1 is a selective inhibitor of bone morphogenic protein (BMP) type-I receptor activin receptor-like kinase 2 (ALK2) receptor (IC50 = 108 nM or 12.6 nM in in vitro kinase assays). DMH-1 exhibits 6- and 19-fold selectivity for ALK-2 over ALK-1 and ALK-3, respectively, and no significant inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFR receptors. DMH-1 blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614). DMH-1 suppresses lung cancer cell proliferation, migration, invasion in vitro and reduces tumor growth in a mouse lung cancer xenograft model. DMH-1 inhibits cellular autophagy responses. DMH-1 induces intestinal differentiation in human intestinal organoids (hIOs) derived from human pluripotent stems cells (hPSCs). The compound can also be used in protocols for the chemical reprogramming of somatic cells to iPSCs.
top caption :
Selective ALK2 inhibitor
extended description :
Selective ALK2 inhibitor
chemical name text :
4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
formula :
C24H20N4O
formula text :
C24H20N4O
cas num :
1206711-16-1
USD :
299 USD
product details :
Selective ALK2 inhibitor
storage :
Store at +4░C
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK