HC 067047 | Tocris Bioscience 4100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

HC 067047

catalog :

4100

quantity :

10 mg (also 50 mg)

price :

223 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Zhao R, Afthinos A, Zhu T, Mistriotis P, Li Y, Serra S, et al. Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. Sci Adv. 2019;5:eaaw7243 pubmed publisher
Mundt N, Spehr M, Lishko P. TRPV4 is the temperature-sensitive ion channel of human sperm. elife. 2018;7: pubmed publisher
Oliván Viguera A, Garcia Otin A, Lozano Gerona J, Abarca Lachen E, García Malinis A, Hamilton K, et al. Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. PLoS ONE. 2018;13:e0190307 pubmed publisher
Yu Z, Wang Y, Qin L, Chen H. Functional Cooperation between KCa3.1 and TRPV4 Channels in Bronchial Smooth Muscle Cell Proliferation Associated with Chronic Asthma. Front Pharmacol. 2017;8:559 pubmed publisher
Kim K, Iddings J, Stern J, Blanco V, Croom D, Kirov S, et al. Astrocyte contributions to flow/pressure-evoked parenchymal arteriole vasoconstriction. J Neurosci. 2015;35:8245-57 pubmed publisher
Vizin R, Scarpellini C, Ishikawa D, Correa G, de Souza C, Gargaglioni L, et al. TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats. Acta Physiol (Oxf). 2015;214:275-89 pubmed publisher
Son G, Yang Y, Park W, Chang I, Shin D. Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. J Dent Res. 2015;94:473-81 pubmed publisher
Merrill L, Vizzard M. Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats. Am J Physiol Regul Integr Comp Physiol. 2014;307:R471-80 pubmed publisher
Garcia Elias A, Mrkonjic S, Pardo Pastor C, Inada H, Hellmich U, Rubio Moscardo F, et al. Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Proc Natl Acad Sci U S A. 2013;110:9553-8 pubmed publisher
Trevisan G, Materazzi S, Fusi C, Altomare A, Aldini G, Lodovici M, et al. Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade. Cancer Res. 2013;73:3120-31 pubmed publisher
Shahidullah M, Mandal A, Delamere N. TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity. Am J Physiol Cell Physiol. 2012;302:C1751-61 pubmed publisher
Jin M, Berrout J, Chen L, O Neil R. Hypotonicity-induced TRPV4 function in renal collecting duct cells: modulation by progressive cross-talk with Ca2+-activated K+ channels. Cell Calcium. 2012;51:131-9 pubmed publisher
Klinger A, Pichette B, Sobolewski P, Eckmann D. Mechanotransductional basis of endothelial cell response to intravascular bubbles. Integr Biol (Camb). 2011;3:1033-42 pubmed publisher

image

image 1 :

Cat.No. 4100 - HC 067047 C26H28F3N3O2 CAS No. 883031-03-6

product information

brand :

Tocris

master code :

4100

SKU :

4100/10

product name :

HC 067047

description :

Potent and selective TRPV4 antagonist

target :

TRPV Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

471.51

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective TRPV4 antagonist. Reversibly inhibits currents through mouse, human and rat TRPV4 orthologs (IC50 values are 17, 48 and 133 nM respectively). Also inhibits the endogenous TRPV4-mediated response to 4 -PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.

catalog number base :

4100

product keywords :

HC067047 trpv4 transient receptor potential channels potent selective antagonists TRPV 4100,

extended description :

Potent and selective TRPV4 antagonist

chemical name text :

2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

formula :

C 26 H 28 F 3 N 3 O 2

formula text :

C26H28F3N3O2

cas num :

883031-03-6

2020 USD :

214

2021 USD :

223 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage