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company name :
Tocris Bioscience
product type :
chemical
product name :
HC 067047
catalog :
4100/10
quantity :
10 mg (also 50 mg)
price :
287 USD
more info or order :
citations: 27
Reference
Hossain M, Tolosa J, Young R, Smith R, Paul J. Assessing the Potency of the Novel Tocolytics 2-APB, Glycyl-H-1152, and HC-067047 in Pregnant Human Myometrium. Reprod Sci. 2023;30:203-220 pubmed publisher
Swain S, Romac J, Vigna S, Liddle R. Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice. JCI Insight. 2022;7: pubmed publisher
Norton C, Shaw R, Mittler R, Segal S. Endothelial cells promote smooth muscle cell resilience to H2 O2 -induced cell death in mouse cerebral arteries. Acta Physiol (Oxf). 2022;235:e13819 pubmed publisher
Hu Y, Fu Q, Fu D, Wang X, Wang Z, Zhang J, et al. The Role of Transient Receptor Potential A1 and G Protein-Coupled Receptor 39 in Zinc-Mediated Acute and Chronic Itch in Mice. Front Mol Neurosci. 2021;14:768731 pubmed publisher
Haidey J, Peringod G, Institoris A, Gorzo K, Nicola W, Vandal M, et al. Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback. Cell Rep. 2021;36:109405 pubmed publisher
Liu X, Zhang J, Hu Y, Shan W, Wang Z, Fu Q, et al. Formalin Itch Test: Low-Dose Formalin Induces Histamine-Independent, TRPA1-Mediated Itch in Mice. Front Med (Lausanne). 2021;8:627725 pubmed publisher
Swain S, Liddle R. Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress. J Biol Chem. 2021;296:100171 pubmed publisher
Llori xe1 n Salvador M, Barabas P, Byrne E, Lechner J, Augustine J, Curtis T, et al. VEGF-B Is an Autocrine Gliotrophic Factor for Müller Cells under Pathologic Conditions. Invest Ophthalmol Vis Sci. 2020;61:35 pubmed publisher
Garth J, Easter M, Skylar Harris E, Sailland J, Kuenzi L, Chung S, et al. The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance. Front Med (Lausanne). 2019;6:339 pubmed publisher
Swain S, Romac J, Shahid R, Pandol S, Liedtke W, Vigna S, et al. TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation. J Clin Invest. 2020;130:2527-2541 pubmed publisher
Norton C, Jacobsen N, Sinkler S, Manrique Acevedo C, Segal S. Female sex and Western-style diet protect mouse resistance arteries during acute oxidative stress. Am J Physiol Cell Physiol. 2020;318:C627-C639 pubmed publisher
Zhao R, Afthinos A, Zhu T, Mistriotis P, Li Y, Serra S, et al. Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. Sci Adv. 2019;5:eaaw7243 pubmed publisher
Mundt N, Spehr M, Lishko P. TRPV4 is the temperature-sensitive ion channel of human sperm. elife. 2018;7: pubmed publisher
Oliván Viguera A, Garcia Otin A, Lozano Gerona J, Abarca Lachen E, García Malinis A, Hamilton K, et al. Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. PLoS ONE. 2018;13:e0190307 pubmed publisher
Yu Z, Wang Y, Qin L, Chen H. Functional Cooperation between KCa3.1 and TRPV4 Channels in Bronchial Smooth Muscle Cell Proliferation Associated with Chronic Asthma. Front Pharmacol. 2017;8:559 pubmed publisher
Akiyama T, Ivanov M, Nagamine M, Davoodi A, Carstens M, Ikoma A, et al. Involvement of TRPV4 in Serotonin-Evoked Scratching. J Invest Dermatol. 2016;136:154-160 pubmed publisher
Kim K, Iddings J, Stern J, Blanco V, Croom D, Kirov S, et al. Astrocyte contributions to flow/pressure-evoked parenchymal arteriole vasoconstriction. J Neurosci. 2015;35:8245-57 pubmed publisher
Peixoto Neves D, Wang Q, Leal Cardoso J, Rossoni L, Jaggar J. Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV4 channels. Br J Pharmacol. 2015;172:3484-94 pubmed publisher
Vizin R, Scarpellini C, Ishikawa D, Correa G, de Souza C, Gargaglioni L, et al. TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats. Acta Physiol (Oxf). 2015;214:275-89 pubmed publisher
Son G, Yang Y, Park W, Chang I, Shin D. Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. J Dent Res. 2015;94:473-81 pubmed publisher
Merrill L, Vizzard M. Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats. Am J Physiol Regul Integr Comp Physiol. 2014;307:R471-80 pubmed publisher
Alenmyr L, Uller L, Greiff L, Hogestatt E, Zygmunt P. TRPV4-mediated calcium influx and ciliary activity in human native airway epithelial cells. Basic Clin Pharmacol Toxicol. 2014;114:210-6 pubmed publisher
Garcia Elias A, Mrkonjic S, Pardo Pastor C, Inada H, Hellmich U, Rubio Moscardo F, et al. Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Proc Natl Acad Sci U S A. 2013;110:9553-8 pubmed publisher
Trevisan G, Materazzi S, Fusi C, Altomare A, Aldini G, Lodovici M, et al. Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade. Cancer Res. 2013;73:3120-31 pubmed publisher
Shahidullah M, Mandal A, Delamere N. TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity. Am J Physiol Cell Physiol. 2012;302:C1751-61 pubmed publisher
Jin M, Berrout J, Chen L, O Neil R. Hypotonicity-induced TRPV4 function in renal collecting duct cells: modulation by progressive cross-talk with Ca2+-activated K+ channels. Cell Calcium. 2012;51:131-9 pubmed publisher
Klinger A, Pichette B, Sobolewski P, Eckmann D. Mechanotransductional basis of endothelial cell response to intravascular bubbles. Integr Biol (Camb). 2011;3:1033-42 pubmed publisher
image
image 1 :
Tocris Bioscience 4100/10 image 1
Cat.No. 4100 - HC 067047 C26H28F3N3O2 CAS No. 883031-03-6
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
4100
SKU :
4100/10
product name :
HC 067047
description :
Potent and selective TRPV4 antagonist
target :
TRPV Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Store at +4°C
observed molecular weight :
471.51
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
HC 067047 is a potent and selective TRPV4 antagonist. Reversibly inhibits currents through mouse, human and rat TRPV4 orthologs (IC50 values are 17, 48 and 133 nM respectively). Also inhibits the endogenous TRPV4-mediated response to 4 -PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.
product keywords :
HC067047 trpv4 transient receptor potential channels potent selective antagonists TRPV 4100,
extended description :
Potent and selective TRPV4 antagonist
chemical name text :
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
formula :
C26H28F3N3O2
formula text :
C26H28F3N3O2
cas num :
883031-03-6
USD :
278
USD 2025 :
287 USD
product details :
Potent and selective TRPV4 antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK