Niclosamide | Tocris Bioscience 4079 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Niclosamide

catalog :

4079

quantity :

50 mg

price :

106 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Natarajan R, Singal V, Benes R, Gao J, Chan H, Chen H, et al. STAT3 modulation to enhance motor neuron differentiation in human neural stem cells. PLoS ONE. 2014;9:e100405 pubmed publisher

product information

brand :

Tocris

master code :

4079

SKU :

4079/50

product name :

Niclosamide

description :

STAT3 inhibitor; also inhibits mTORC1 signaling

target :

STAT Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

99%

observed molecular weight :

325.99

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of the STAT3 signaling pathway; inhibits the activation, nuclear translocation and transactivation of STAT3. Displays selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. Inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro ; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.

catalog number base :

4079

product keywords :

STAT3 mTORC1 signaling signalling pathway inhibitors inhibits anthelmintic STAT mTOR Stem Cell Signaling Autophagy Cancer Stem Cells 4079,

extended description :

STAT3 inhibitor; also inhibits mTORC1 signaling

chemical name text :

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

formula :

C 13 H 8 Cl 2 N 2 O 4

formula text :

C13H8Cl2N2O4

cas num :

50-65-7

2020 USD :

102

2021 USD :

106 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage