Niclosamide | Tocris Bioscience 4079/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Niclosamide

catalog :

4079/50

quantity :

50 mg

price :

132 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Xia Y, Wang G, Jiang M, Liu X, Zhao Y, Song Y, et al. A Novel Biological Activity of the STAT3 Inhibitor Stattic in Inhibiting Glutathione Reductase and Suppressing the Tumorigenicity of Human Cervical Cancer Cells via a ROS-Dependent Pathway. Onco Targets Ther. 2021;14:4047-4060 pubmed publisher
Mishra S, Wheeler J, Pitake S, Ding H, Jiang C, Fukuyama T, et al. Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. Cell Rep. 2020;31:107472 pubmed publisher
Jang B, Ishigami A, Kim Y, Choi E. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells. Int J Mol Sci. 2017;18: pubmed publisher
Natarajan R, Singal V, Benes R, Gao J, Chan H, Chen H, et al. STAT3 modulation to enhance motor neuron differentiation in human neural stem cells. PLoS ONE. 2014;9:e100405 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4079

SKU :

4079/50

product name :

Niclosamide

Description :

STAT3 inhibitor; also inhibits mTORC1 signaling

target :

STAT Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

99%

observed molecular weight :

325.99

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Niclosamide is an inhibitor of the STAT3 signaling pathway; inhibits the activation, nuclear translocation and transactivation of STAT3. Niclosamide displays selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. It inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3. It also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro ; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells. In addition, niclosamide inhibits SARS-CoV-2 replication in vitro (IC50 = 0.34 M in Vero E6 plaque assay) through suppression of TMEM16F activity.

extended description :

STAT3 inhibitor; also inhibits mTORC1 signaling

chemical name text :

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

formula :

C 13 H 8 Cl 2 N 2 O 4

formula text :

C13H8Cl2N2O4

cas num :

50-65-7

USD :

132 USD

product details :

STAT3 inhibitor; also inhibits mTORC1 signaling

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage