TCN 237 dihydrochloride | Tocris Bioscience 4072 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TCN 237 dihydrochloride

catalog :

4072

quantity :

10 mg

price :

187 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4072

SKU :

4072/10

product name :

TCN 237 dihydrochloride

description :

Highly potent and selective GluN2B NMDA antagonist

target :

NMDA Receptor Antagonists

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

412.33

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent GluN2B (formally NR2B) selective NMDA receptor antagonist (Ki = 0.8 nM); blocks GluN2B-mediated calcium influx in Ltk cells (Ki = 9.7 nM). Selective for GluN2B subunit over 1-adrenergic receptors and hERG channels (IC50 values are 730 nM and 2900 nM respectively). Displays efficacy in the rat carrageenan-induced mechanical hyperalgesia assay. . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

catalog number base :

4072

product keywords :

TCN237 dihydrochloride NR2B NMDA antagonists highly potent selective analgesic in vivo GluN2B NMDA Receptors 4072,

extended description :

Highly potent and selective GluN2B NMDA antagonist

chemical name text :

2-[[4-[(2-Fluorophenyl)methyl]-1-piperidinyl]methyl]-1H-benzimidazol-6-ol dihydrochloride

formula :

C 20 H 22 FN 3 O.2HCl

formula text :

C20H22FN3O.2HCl

cas num :

700878-19-9

2020 USD :

183

2021 USD :

187 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage