TC-A 2317 hydrochloride | Tocris Bioscience 4066/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TC-A 2317 hydrochloride

catalog :

4066/10

quantity :

10 mg (also 50 mg)

price :

320 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Wang Y, Feige P, Brun C, Hekmatnejad B, Dumont N, Renaud J, et al. EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions. Cell Stem Cell. 2019;24:419-432.e6 pubmed publisher
Rai A, Chen J, Selbach M, Pelkmans L. Kinase-controlled phase transition of membraneless organelles in mitosis. Nature. 2018;559:211-216 pubmed publisher
Min Y, Kim W, Kim J. The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation. Oncotarget. 2016;7:84718-84735 pubmed publisher

image

image 1 :

Cat.No. 4066 - TC-A 2317 hydrochloride C19H28N6O.HCl CAS No. 1245907-03-2

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4066

SKU :

4066/10

product name :

TC-A 2317 hydrochloride

Description :

Potent, selective Aurora kinase A inhibitor

target :

Aurora Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

392.93

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TC-A 2317 hydrochloride is a potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values 1000 nM). Exhibits good cell permeability and antitumor activity.

extended description :

Potent, selective Aurora kinase A inhibitor

chemical name text :

2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride

formula :

C 19 H 28 N 6 O.HCl

formula text :

C19H28N6O.HCl

cas num :

1245907-03-2

USD :

320 USD

product details :

Potent, selective Aurora kinase A inhibitor

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage