Docetaxel | Tocris Bioscience 4056 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Docetaxel

catalog :

4056

quantity :

10 mg (also 50 mg)

price :

151 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Mabe N, Fox D, Lupo R, Decker A, Phelps S, Thompson J, et al. Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. J Clin Invest. 2018;128:4413-4428 pubmed publisher
Zhang H, Patel A, Wang Y, Zhang Y, Kathawala R, Qiu L, et al. The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors. Mol Cancer Ther. 2017;16:1021-1030 pubmed publisher
Kathawala R, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, et al. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 2015;6:510-21 pubmed
Kathawala R, Sodani K, Chen K, Patel A, Abuznait A, Anreddy N, et al. Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study. Mol Cancer Ther. 2014;13:714-23 pubmed publisher

product information

brand :

Tocris

master code :

4056

SKU :

4056/10

product name :

Docetaxel

description :

Microtubule stabilizer

target :

Microtubule Binding Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

807.88

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric tumors. Prevents microtubule depolymerization and disassembly in the absence of GTP. Exhibits cytotoxic activity.

catalog number base :

4056

product keywords :

cancer therapy antitumor binds stabilizes microtubules microtubule stabilizers chemotherapeutics Microtubules 4056,

extended description :

Microtubule stabilizer

chemical name text :

[2aR-[2a ,4 ,4a ,6 ,9 ( R*, S*),11 ,12 ,12a ,12b ]]- -[[(1,1-Dimethylethoxy)carbonyl]amino]- -hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trih

formula :

C 43 H 53 NO 14

formula text :

C43H53NO14

cas num :

114977-28-5

2020 USD :

145

2021 USD :

151 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage