PEP 005 | Tocris Bioscience 4054 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PEP 005

catalog :

4054

quantity :

1 mg

price :

225 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Jiang G, Mendes E, Kaiser P, Wong D, Tang Y, Cai I, et al. Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation. PLoS Pathog. 2015;11:e1005066 pubmed publisher

product information

brand :

Tocris

master code :

4054

SKU :

4054/1

product name :

PEP 005

description :

Protein kinase C activator

target :

Protein Kinase C Activators

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

430.53

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Activator of protein kinase C (PKC). Exhibits antileukemic activity; induces nuclear translocation of PKC , and induces apoptosis in acute myeloid leukemia (AML) cell lines and primary AML blast cells. Also displays antiproliferative effects and induces apoptosis in Colo205 cells. Reactivates latent HIV in cell culture. Also reactivates hypofunctional CD8+ T cells during chronic viral infection. Acts as a substrate for multidrug transporter.

catalog number base :

4054

product keywords :

Ingenol 3-angelate PEP005 protein kinase C PKC activators anticancer antileukemic PKCd PKCdelta PKC T cells exhaustion CD8 hypofunction ingenol mebuate IngMb Ingenol 3-angelate Ingenol Mebutate Protein Kinase C Multidrug Transporters 4054,

extended description :

Protein kinase C activator

chemical name text :

(2Z)-2-Methyl-2-butenoic acid (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester

formula :

C 25 H 34 O 6

formula text :

C25H34O6

cas num :

75567-37-2

2020 USD :

216

2021 USD :

225 USD

alt names :

Ingenol 3-angelate, Ingenol Mebutate

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage