PSC 833 | Tocris Bioscience 4042 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PSC 833

catalog :

4042

quantity :

1 mg

price :

269 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Kim D, Bynoe M. A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. J Clin Invest. 2016;126:1717-33 pubmed publisher
Slosky L, Thompson B, Sanchez Covarrubias L, Zhang Y, Laracuente M, Vanderah T, et al. Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism. Mol Pharmacol. 2013;84:774-86 pubmed publisher
Ong H, Traini D, Bebawy M, Young P. Ciprofloxacin is actively transported across bronchial lung epithelial cells using a Calu-3 air interface cell model. Antimicrob Agents Chemother. 2013;57:2535-40 pubmed publisher
Elbaradie K, Wang Y, Boyan B, Schwartz Z. Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17?-estradiol involves differential regulation of plasma membrane associated estrogen receptors. Biochim Biophys Acta. 2013;1833:1165-72 pubmed publisher
Lipka D, Wagner M, Dziadosz M, Schnöder T, Heidel F, Schemionek M, et al. Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells. PLoS ONE. 2012;7:e40853 pubmed publisher

product information

brand :

Tocris

master code :

4042

SKU :

4042/1

product name :

PSC 833

description :

Inhibitor of P-gp-mediated MDR

target :

Multidrug Transporter Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

1214.62

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).

catalog number base :

4042

product keywords :

PSC833 P-glycoprotein inhibitors inhibits P-gp cyclosporin A analog analogue ABCB1 Valspodar Multidrug Transporters 4042,

extended description :

Inhibitor of P-gp-mediated MDR

chemical name text :

6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A

formula :

C 63 H 111 N 11 O 12

formula text :

C63H111N11O12

cas num :

121584-18-7

2020 USD :

258

2021 USD :

269 USD

alt names :

Valspodar

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage