PSC 833 | Tocris Bioscience 4042/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PSC 833

catalog :

4042/1

quantity :

1 mg

price :

312 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Kim D, Bynoe M. A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. J Clin Invest. 2016;126:1717-33 pubmed publisher
Slosky L, Thompson B, Sanchez Covarrubias L, Zhang Y, Laracuente M, Vanderah T, et al. Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism. Mol Pharmacol. 2013;84:774-86 pubmed publisher
Ong H, Traini D, Bebawy M, Young P. Ciprofloxacin is actively transported across bronchial lung epithelial cells using a Calu-3 air interface cell model. Antimicrob Agents Chemother. 2013;57:2535-40 pubmed publisher
Elbaradie K, Wang Y, Boyan B, Schwartz Z. Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17?-estradiol involves differential regulation of plasma membrane associated estrogen receptors. Biochim Biophys Acta. 2013;1833:1165-72 pubmed publisher
Lipka D, Wagner M, Dziadosz M, Schnöder T, Heidel F, Schemionek M, et al. Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells. PLoS ONE. 2012;7:e40853 pubmed publisher

product information

brand :

Tocris

master code :

4042

SKU :

4042/1

rank :

0.061

product name :

PSC 833

description :

Inhibitor of P-gp-mediated MDR

target :

Multidrug Transporter Inhibitors

category :

Small Molecules

sizes available :

1 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PSC 833 is a P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).

extended description :

Inhibitor of P-gp-mediated MDR

chemical name text :

6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A

formula :

C 63 H 111 N 11 O 12

formula text :

C63H111N11O12

cas num :

121584-18-7

USD :

312 USD

product details :

Inhibitor of P-gp-mediated MDR

alt names :

Valspodar

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage