PF 4708671 | Tocris Bioscience 4032 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 4708671

catalog :

4032

quantity :

25 mg

price :

476 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Xing T, Hass D, Zhang S, Barnstable C. The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development. Front Cell Dev Biol. 2018;6:134 pubmed publisher
Pirbhoy P, Farris S, Steward O. Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways. Learn Mem. 2017;24:341-357 pubmed publisher
Sinha R, Singh B, Zhou J, Xie S, Farah B, Lesmana R, et al. Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. Autophagy. 2017;13:169-186 pubmed publisher
Salmond R, Brownlie R, Meyuhas O, Zamoyska R. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation. J Immunol. 2015;195:4615-22 pubmed publisher
Hullinger R, O Riordan K, Burger C. Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k. Neurobiol Learn Mem. 2015;125:126-34 pubmed publisher
Arnold N, Koppula P, Gul R, Lück C, Pulakat L. Regulation of cardiac expression of the diabetic marker microRNA miR-29. PLoS ONE. 2014;9:e103284 pubmed publisher
Al Ejeh F, Miranda M, Shi W, Simpson P, Song S, Vargas A, et al. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget. 2014;5:3145-58 pubmed
Melemedjian O, Khoutorsky A, Sorge R, Yan J, Asiedu M, Valdez A, et al. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain. 2013;154:1080-91 pubmed publisher
Wang H, Brown J, Gu Z, Garcia C, Liang R, Alard P, et al. Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-?-signaling pathways regulates the innate inflammatory response. J Immunol. 2011;186:5217-26 pubmed publisher

product information

brand :

Tocris

master code :

4032

SKU :

4032/25

product name :

PF 4708671

description :

S6K1 inhibitor

target :

RSK Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

390.41

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki = 20 nM; IC50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo . Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro .

catalog number base :

4032

product keywords :

PF4708671 selective inhibitor inhibitors p70 ribosomal S6 kinase S6K1 inhibits cancer Pfizer RSK 4032,

extended description :

S6K1 inhibitor

chemical name text :

2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole

formula :

C 19 H 21 F 3 N 6

formula text :

C19H21F3N6

cas num :

1255517-76-0

2020 USD :

457

2021 USD :

476 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage