PF 4708671 | Tocris Bioscience 4032/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 4708671

catalog :

4032/5

quantity :

5 mg (also 25 mg)

price :

158 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
Shaiken T, Grimm S, Siam M, Williams A, Rezaeian A, Kraushaar D, et al. Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix. iScience. 2023;26:105965 pubmed publisher
Atanasova V, Riedl A, Strobl M, Flandorfer J, Unterleuthner D, Weindorfer C, et al. Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK Inhibition. Int J Mol Sci. 2023;24: pubmed publisher
Lee M, Oh H, Park J, You J, Han J. Nuclear S6K1 Enhances Oncogenic Wnt Signaling by Inducing Wnt/β-Catenin Transcriptional Complex Formation. Int J Mol Sci. 2022;23: pubmed publisher
Yi S, Jeon Y, Lee M, Nam K, Ann S, Lee J, et al. S6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2. Exp Mol Med. 2022;54:324-333 pubmed publisher
Raj N, McEachin Z, Harousseau W, Zhou Y, Zhang F, Merritt Garza M, et al. Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis. Cell Rep. 2021;35:108991 pubmed publisher
Okita R, Shimizu K, Nojima Y, Saisho S, Nakata M. Tofacitinib overcomes an IFNγ-induced decrease in NK cell-mediated cytotoxicity via the regulation of immune-related molecules in LC-2/ad. Thorac Cancer. 2021;12:775-782 pubmed publisher
Jia J, Lahr R, Solgaard M, Moraes B, Pointet R, Yang A, et al. mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1. Nucleic Acids Res. 2021;49:3461-3489 pubmed publisher
Domingues A, Kulkarni R, Giotopoulos G, Gupta S, Vinnenberg L, Arede L, et al. Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells. elife. 2020;9: pubmed publisher
Xing T, Hass D, Zhang S, Barnstable C. The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development. Front Cell Dev Biol. 2018;6:134 pubmed publisher
Pirbhoy P, Farris S, Steward O. Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways. Learn Mem. 2017;24:341-357 pubmed publisher
Nguyen McCarty M, Klein P. Autophagy is a signature of a signaling network that maintains hematopoietic stem cells. PLoS ONE. 2017;12:e0177054 pubmed publisher
Sinha R, Singh B, Zhou J, Xie S, Farah B, Lesmana R, et al. Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. Autophagy. 2017;13:169-186 pubmed publisher
Salmond R, Brownlie R, Meyuhas O, Zamoyska R. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation. J Immunol. 2015;195:4615-22 pubmed publisher
Hullinger R, O Riordan K, Burger C. Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k. Neurobiol Learn Mem. 2015;125:126-34 pubmed publisher
Arnold N, Koppula P, Gul R, Lück C, Pulakat L. Regulation of cardiac expression of the diabetic marker microRNA miR-29. PLoS ONE. 2014;9:e103284 pubmed publisher
Al Ejeh F, Miranda M, Shi W, Simpson P, Song S, Vargas A, et al. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget. 2014;5:3145-58 pubmed
Melemedjian O, Khoutorsky A, Sorge R, Yan J, Asiedu M, Valdez A, et al. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain. 2013;154:1080-91 pubmed publisher
Wang H, Brown J, Gu Z, Garcia C, Liang R, Alard P, et al. Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-?-signaling pathways regulates the innate inflammatory response. J Immunol. 2011;186:5217-26 pubmed publisher

image

image 1 :

Cat.No. 4032 - PF 4708671 C19H21F3N6 CAS No. 1255517-76-0

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4032

SKU :

4032/5

product name :

PF 4708671

description :

S6K1 inhibitor

target :

RSK Inhibitors

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

390.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki = 20 nM; IC50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo . Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro .

product keywords :

PF4708671 selective inhibitor inhibitors p70 ribosomal S6 kinase S6K1 inhibits cancer Pfizer RSK 4032,

extended description :

S6K1 inhibitor

chemical name text :

2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole

formula :

C19H21F3N6

formula text :

C19H21F3N6

cas num :

1255517-76-0

USD :

156

USD 2025 :

158 USD

product details :

S6K1 inhibitor

more info or order :

Tocris Bioscience product webpage