IDE 2 | Tocris Bioscience 4016/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IDE 2

catalog :

4016/10

quantity :

10 mg

price :

202 USD

citations: 1

Reference
Borowiak M, Maehr R, Chen S, Chen A, Tang W, Fox J, et al. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 2009;4:348-58 pubmed publisher

product information

brand :

Tocris

master code :

4016

SKU :

4016/10

product name :

IDE 2

description :

Induces definitive endoderm formation in mouse and human ESCs

target :

Compounds for Stem Cell Differentiation

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

240.3

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

IDE 2 is a cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs). Reported to activate TGF- signaling and downstream Smad2 phosphorylation; upregulates Nodal expression. Promotes pancreatic progenitor cell formation in vitro , and gut tube formation in vivo .

catalog number base :

4016

extended description :

Induces definitive endoderm formation in mouse and human ESCs

chemical name text :

Heptanedioic acid-1-(2-cyclopentylidenehydrazide)

formula :

C 12 H 20 N 2 O 3

formula text :

C12H20N2O3

cas num :

1136466-93-7

USD 2021 :

191

USD 2022 :

202 USD

product details :

Induces definitive endoderm formation in mouse and human ESCs

storage :

Store at +4°C