GSK 269962 | Tocris Bioscience 4009 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 269962

catalog :

4009

quantity :

10 mg (also 50 mg)

price :

292 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Jiang L, Paone S, Caruso S, Atkin Smith G, Phan T, Hulett M, et al. Determining the contents and cell origins of apoptotic bodies by flow cytometry. Sci Rep. 2017;7:14444 pubmed publisher
Han C, Juncadella I, Kinchen J, Buckley M, Klibanov A, Dryden K, et al. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation. Nature. 2016;539:570-574 pubmed publisher
Lotz Jenne C, Lüthi U, Ackerknecht S, Lehembre F, Fink T, Stritt M, et al. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. Oncotarget. 2016;7:25983-6002 pubmed publisher
Galea G, Meakin L, Savery D, Taipaleenmaki H, Delisser P, Stein G, et al. Planar cell polarity aligns osteoblast division in response to substrate strain. J Bone Miner Res. 2015;30:423-35 pubmed publisher
Evron T, Peterson S, Urs N, Bai Y, Rochelle L, Caron M, et al. G Protein and Î²-arrestin signaling bias at the ghrelin receptor. J Biol Chem. 2014;289:33442-55 pubmed publisher
Hutchinson J, Rajagopal S, Yuan M, Norman J. Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways. FASEB J. 2014;28:94-105 pubmed publisher

product information

brand :

Tocris

master code :

4009

SKU :

4009/10

product name :

GSK 269962

description :

Potent and selective ROCK inhibitor

target :

Rho-kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

570.6

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension.

catalog number base :

4009

product keywords :

glaxosmithkline rock rho kinases rock1 rock2 potent selective inhibitors inhibits antihypertensive hypotensive GSK269962 Rho-kinases 4009,

extended description :

Potent and selective ROCK inhibitor

chemical name text :

N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide

formula :

C 29 H 30 N 8 O 5

formula text :

C29H30N8O5

cas num :

850664-21-0

2020 USD :

280

2021 USD :

292 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage