GSK 269962 | Tocris Bioscience 4009/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 269962

catalog :

4009/10

quantity :

10 mg (also 50 mg)

price :

339 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Jiang L, Paone S, Caruso S, Atkin Smith G, Phan T, Hulett M, et al. Determining the contents and cell origins of apoptotic bodies by flow cytometry. Sci Rep. 2017;7:14444 pubmed publisher
Han C, Juncadella I, Kinchen J, Buckley M, Klibanov A, Dryden K, et al. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation. Nature. 2016;539:570-574 pubmed publisher
Lotz Jenne C, Lüthi U, Ackerknecht S, Lehembre F, Fink T, Stritt M, et al. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. Oncotarget. 2016;7:25983-6002 pubmed publisher
Galea G, Meakin L, Savery D, Taipaleenmaki H, Delisser P, Stein G, et al. Planar cell polarity aligns osteoblast division in response to substrate strain. J Bone Miner Res. 2015;30:423-35 pubmed publisher
Evron T, Peterson S, Urs N, Bai Y, Rochelle L, Caron M, et al. G Protein and Î²-arrestin signaling bias at the ghrelin receptor. J Biol Chem. 2014;289:33442-55 pubmed publisher
Hutchinson J, Rajagopal S, Yuan M, Norman J. Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways. FASEB J. 2014;28:94-105 pubmed publisher

image

image 1 :

Cat.No. 4009 - GSK 269962 C29H30N8O5 CAS No. 850664-21-0

product information

brand :

Tocris

master code :

4009

SKU :

4009/10

rank :

0.061

product name :

GSK 269962

description :

Potent and selective ROCK inhibitor

target :

Rho-kinase Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 269962 is a potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension.

extended description :

Potent and selective ROCK inhibitor

chemical name text :

N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide

formula :

C 29 H 30 N 8 O 5

formula text :

C29H30N8O5

cas num :

850664-21-0

USD :

339 USD

product details :

Potent and selective ROCK inhibitor

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage