GSK 269962 | Tocris Bioscience 4009/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 269962

catalog :

4009/10

quantity :

10 mg (also 50 mg)

price :

367 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Hong Y, Dong X, Chang L, Xie C, Chang M, Aguilar J, et al. Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases. iScience. 2023;26:106267 pubmed publisher
Turner R, Golz S, Wollnik C, Burkhardt N, Sternberger I, Andag U, et al. A Whole Genome-Wide Arrayed CRISPR Screen in Primary Organ Fibroblasts to Identify Regulators of Kidney Fibrosis. SLAS Discov. 2020;25:591-604 pubmed publisher
Matthews H, Ganguli S, Plak K, Taubenberger A, Win Z, Williamson M, et al. Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement. Dev Cell. 2020;52:563-573.e3 pubmed publisher
Park D, Wershof E, Boeing S, Labernadie A, Jenkins R, George S, et al. Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions. Nat Mater. 2020;19:227-238 pubmed publisher
Da Silva B, Irving B, Polson E, Droop A, Griffiths H, Mathew R, et al. Chemically induced neurite-like outgrowth reveals a multicellular network function in patient-derived glioblastoma cells. J Cell Sci. 2019;132: pubmed publisher
He L, Kulesskiy E, Saarela J, Turunen L, Wennerberg K, Aittokallio T, et al. Methods for High-throughput Drug Combination Screening and Synergy Scoring. Methods Mol Biol. 2018;1711:351-398 pubmed publisher
Jiang L, Paone S, Caruso S, Atkin Smith G, Phan T, Hulett M, et al. Determining the contents and cell origins of apoptotic bodies by flow cytometry. Sci Rep. 2017;7:14444 pubmed publisher
Han C, Juncadella I, Kinchen J, Buckley M, Klibanov A, Dryden K, et al. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation. Nature. 2016;539:570-574 pubmed publisher
Lotz Jenne C, Lüthi U, Ackerknecht S, Lehembre F, Fink T, Stritt M, et al. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. Oncotarget. 2016;7:25983-6002 pubmed publisher
Galea G, Meakin L, Savery D, Taipaleenmaki H, Delisser P, Stein G, et al. Planar cell polarity aligns osteoblast division in response to substrate strain. J Bone Miner Res. 2015;30:423-35 pubmed publisher
Evron T, Peterson S, Urs N, Bai Y, Rochelle L, Caron M, et al. G Protein and Î²-arrestin signaling bias at the ghrelin receptor. J Biol Chem. 2014;289:33442-55 pubmed publisher
Hutchinson J, Rajagopal S, Yuan M, Norman J. Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways. FASEB J. 2014;28:94-105 pubmed publisher

image

image 1 :

Cat.No. 4009 - GSK 269962 C29H30N8O5 CAS No. 850664-21-0

product information

brand :

Tocris

catalog number base :

4009

SKU :

4009/10

product name :

GSK 269962

units size :

10 mg (also 50 mg)

description :

Potent and selective ROCK inhibitor

target :

Rho-kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

570.6

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 269962 is a potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension.

top caption :

Potent and selective ROCK inhibitor

extended description :

Potent and selective ROCK inhibitor

chemical name text :

N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide

formula :

C29H30N8O5

formula text :

C29H30N8O5

cas num :

850664-21-0

USD :

367 USD

product details :

Potent and selective ROCK inhibitor

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage