FIIN 1 hydrochloride | Tocris Bioscience 4002/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FIIN 1 hydrochloride

catalog :

4002/10

quantity :

10 mg (also 50 mg)

price :

253 USD

product information

brand :

Tocris

MasterCode :

4002

SKU :

4002/10

product name :

FIIN 1 hydrochloride

unit sizes :

10 mg (also 50 mg)

description :

Potent, irreversible FGFR inhibitor

target :

FGF Receptor Inhibitors

category :

Small Molecules

purity :

96%

observed molecular weight :

693.06

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FIIN 1 hydrochloride is a potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044).

extended description :

Potent, irreversible FGFR inhibitor

chemical name text :

N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide

formula :

C 32 H 39 Cl 2 N 7 O 4

formula text :

C32H39Cl2N7O4

cas num :

1256152-35-8

USD :

253 USD

product details :

Potent, irreversible FGFR inhibitor

storage :

Store at -20°C