MRK 560 | Tocris Bioscience 4000 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MRK 560

catalog :

4000

quantity :

10 mg (also 50 mg)

price :

244 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Lariosa Willingham K, Rosler E, Tung J, Dugas J, Collins T, Leonoudakis D. Development of a central nervous system axonal myelination assay for high throughput screening. BMC Neurosci. 2016;17:16 pubmed publisher
Qi Y, Klyubin I, Harney S, Hu N, Cullen W, Grant M, et al. Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human AÃŸ-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-AÃŸ agents. Acta Neuropathol Commun. 2014;2:175 pubmed publisher
Singh A, Zapata M, Choi Y, Yoon S. GSI promotes vincristine-induced apoptosis by enhancing multi-polar spindle formation. Cell Cycle. 2014;13:157-66 pubmed publisher

product information

brand :

Tocris

master code :

4000

SKU :

4000/10

product name :

MRK 560

description :

-secretase inhibitor; attenuates amyloid plaque deposition

target :

Secretase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

517.92

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

-secretase inhibitor; inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Reduces levels of A in the brain (inhibits A 40 and A 42 in SH-SY5Y neuroblastoma cells with an IC50 of 0.65 nM); attenuates plaque deposition. Orally bioavailable.

catalog number base :

4000

product keywords :

MRK560 gamma-secretase inhibitor g-secretase inhibitors inhibits secretases amyloidbeta amyloidb amyloid Gamma-Secretase Amyloid Beta Peptides 4000,

extended description :

-secretase inhibitor; attenuates amyloid plaque deposition

chemical name text :

N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide

formula :

C 19 H 17 ClF 5 NO 4 S 2

formula text :

C19H17ClF5NO4S2

cas num :

677772-84-8

2020 USD :

234

2021 USD :

244 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage