GI 254023X | Tocris Bioscience 3995/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GI 254023X

catalog :

3995/1

quantity :

1 mg

price :

214 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Mikuličić S, Finke J, Boukhallouk F, Wüstenhagen E, Sons D, Homsi Y, et al. ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly. elife. 2019;8: pubmed publisher
Wang X, Pei G. Visualization of Alzheimer's Disease Related α-/β-/γ-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer. Front Mol Neurosci. 2018;11:431 pubmed publisher
Beerli C, Yakimovich A, Kilcher S, Reynoso G, Fläschner G, Muller D, et al. Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility. Nat Microbiol. 2019;4:216-225 pubmed publisher
Sanz R, Ferraro G, Girouard M, Fournier A. Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons. Sci Rep. 2017;7:7961 pubmed publisher
O Sullivan S, Gasparini F, Mir A, Dev K. Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes. J Neuroinflammation. 2016;13:189 pubmed publisher
Ezekwe E, Weng C, Duncan J. ADAM10 Cell Surface Expression but Not Activity Is Critical for Staphylococcus aureus ?-Hemolysin-Mediated Activation of the NLRP3 Inflammasome in Human Monocytes. Toxins (Basel). 2016;8:95 pubmed publisher
Leoni G, Neumann P, Kamaly N, Quirós M, Nishio H, Jones H, et al. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest. 2015;125:1215-27 pubmed publisher
Gooden M, Wiersma V, Boerma A, Leffers N, Boezen H, Ten Hoor K, et al. Elevated serum CXCL16 is an independent predictor of poor survival in ovarian cancer and may reflect pro-metastatic ADAM protease activity. Br J Cancer. 2014;110:1535-44 pubmed publisher
Moss M, Bomar M, Liu Q, Sage H, Dempsey P, Lenhart P, et al. The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. J Biol Chem. 2007;282:35712-21 pubmed

product information

brand :

Tocris

master code :

3995

SKU :

3995/1

rank :

0.071

product name :

GI 254023X

description :

Selective ADAM10 metalloprotease inhibitor

target :

Synthetic Metalloprotease Inhibitors

category :

Small Molecules

sizes available :

1 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GI 254023X is a selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17. Blocks constitutive release of IL-6R, CX3CL1 and CXCL16 in cell-based cleavage experiments. Inhibits calcium ionophore-induced betacellulin shedding in IMPE cells. Prevents E-cadherin cleavage in A549 cells. Inhibits ADAM10 mediated neuronal outgrowth of dorsal root ganglion neurons in vitro .

extended description :

Selective ADAM10 metalloprotease inhibitor

chemical name text :

(2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide

formula :

C 21 H 33 N 3 O 4

formula text :

C21H33N3O4

cas num :

260264-93-5

USD :

214 USD

product details :

Selective ADAM10 metalloprotease inhibitor

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage