AZ 3146 | Tocris Bioscience 3994 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZ 3146

catalog :

3994

quantity :

10 mg (also 50 mg)

price :

261 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Littler S, Sloss O, Geary B, Pierce A, Whetton A, Taylor S. Oncogenic MYC amplifies mitotic perturbations. Open Biol. 2019;9:190136 pubmed publisher
McKinley K, Stuurman N, Royer L, Schartner C, Castillo Azofeifa D, Delling M, et al. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. elife. 2018;7: pubmed publisher
Drpic D, Almeida A, Aguiar P, Renda F, Damas J, Lewin H, et al. Chromosome Segregation Is Biased by Kinetochore Size. Curr Biol. 2018;28:1344-1356.e5 pubmed publisher
Haase J, Bonner M, Halas H, Kelly A. Distinct Roles of the Chromosomal Passenger Complex in the Detection of and Response to Errors in Kinetochore-Microtubule Attachment. Dev Cell. 2017;42:640-654.e5 pubmed publisher
Karki M, Keyhaninejad N, Shuster C. Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay. Nat Commun. 2017;8:15803 pubmed publisher
Garvanska D, Larsen M, Nilsson J. Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C. Biol Open. 2016;5:1441-1448 pubmed publisher
Bennett A, Bechi B, Tighe A, Thompson S, Procter D, Taylor S. Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy. Oncotarget. 2015;6:20921-32 pubmed
Hermant B, Herman B, Gudrun A, Potopalsky A, Chroboczek J, Tcherniuk S. Amitozyn impairs chromosome segregation and induces apoptosis via mitotic checkpoint activation. PLoS ONE. 2013;8:e57461 pubmed publisher

product information

brand :

Tocris

master code :

3994

SKU :

3994/10

product name :

AZ 3146

description :

Potent and selective Mps1 kinase inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

452.55

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

catalog number base :

3994

product keywords :

AZ astrazeneca Mps1 monopolar spindle selective potent inhibitors inhibits SAC spindle assembly checkpoint control TTK dual-specificity protein kinases kinetochores CENP-E centromere protein E AZ3146 Checkpoint Control Kinases Monopolar Spindle 1 Kinase 3994,

extended description :

Potent and selective Mps1 kinase inhibitor

chemical name text :

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

formula :

C 24 H 32 N 6 O 3

formula text :

C24H32N6O3

cas num :

1124329-14-1

2020 USD :

253

2021 USD :

261 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage