AZ 3146 | Tocris Bioscience 3994/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZ 3146

catalog :

3994/10

quantity :

10 mg (also 50 mg)

price :

329 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Maier N, Ma J, Lampson M, Cheeseman I. Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition. Dev Cell. 2021;56:2192-2206.e8 pubmed publisher
Holder J, Mohammed S, Barr F. Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit. elife. 2020;9: pubmed publisher
Barroso Vilares M, Macedo J, Reis M, Warren J, Compton D, Logarinho E. Small-molecule inhibition of aging-associated chromosomal instability delays cellular senescence. EMBO Rep. 2020;21:e49248 pubmed publisher
Littler S, Sloss O, Geary B, Pierce A, Whetton A, Taylor S. Oncogenic MYC amplifies mitotic perturbations. Open Biol. 2019;9:190136 pubmed publisher
McKinley K, Stuurman N, Royer L, Schartner C, Castillo Azofeifa D, Delling M, et al. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. elife. 2018;7: pubmed publisher
Drpic D, Almeida A, Aguiar P, Renda F, Damas J, Lewin H, et al. Chromosome Segregation Is Biased by Kinetochore Size. Curr Biol. 2018;28:1344-1356.e5 pubmed publisher
He L, Kulesskiy E, Saarela J, Turunen L, Wennerberg K, Aittokallio T, et al. Methods for High-throughput Drug Combination Screening and Synergy Scoring. Methods Mol Biol. 2018;1711:351-398 pubmed publisher
Haase J, Bonner M, Halas H, Kelly A. Distinct Roles of the Chromosomal Passenger Complex in the Detection of and Response to Errors in Kinetochore-Microtubule Attachment. Dev Cell. 2017;42:640-654.e5 pubmed publisher
Karki M, Keyhaninejad N, Shuster C. Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay. Nat Commun. 2017;8:15803 pubmed publisher
McKinley K, Cheeseman I. Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects. Dev Cell. 2017;40:405-420.e2 pubmed publisher
Garvanska D, Larsen M, Nilsson J. Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C. Biol Open. 2016;5:1441-1448 pubmed publisher
Bennett A, Bechi B, Tighe A, Thompson S, Procter D, Taylor S. Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy. Oncotarget. 2015;6:20921-32 pubmed
Peng G, Chun Jen Lin C, Mo W, Dai H, Park Y, Kim S, et al. Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun. 2014;5:3361 pubmed publisher
Hermant B, Herman B, Gudrun A, Potopalsky A, Chroboczek J, Tcherniuk S. Amitozyn impairs chromosome segregation and induces apoptosis via mitotic checkpoint activation. PLoS ONE. 2013;8:e57461 pubmed publisher

image

image 1 :

Cat.No. 3994 - AZ 3146 C24H32N6O3 CAS No. 1124329-14-1

product information

brand :

Tocris

catalog number base :

3994

SKU :

3994/10

product name :

AZ 3146

units size :

10 mg (also 50 mg)

description :

Potent and selective Mps1 kinase inhibitor

target :

TTK/Mps1 Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

452.55

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

top caption :

Potent and selective Mps1 kinase inhibitor

extended description :

Potent and selective Mps1 kinase inhibitor

chemical name text :

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

formula :

C24H32N6O3

formula text :

C24H32N6O3

cas num :

1124329-14-1

USD :

329 USD

product details :

Potent and selective Mps1 kinase inhibitor

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage