EB 1089 | Tocris Bioscience 3993 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

EB 1089

catalog :

3993

quantity :

1 mg

price :

212 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Hiranuma K, Yamada A, Kurosawa T, Aizawa R, Suzuki D, Saito Y, et al. Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3. FEBS Open Bio. 2016;6:914-8 pubmed publisher
Sharma K, Goehe R, Di X, Hicks M, Torti S, Torti F, et al. A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Autophagy. 2014;10:2346-61 pubmed publisher
Solomon J, Heitzer M, Liu T, Beumer J, Parise R, Normolle D, et al. VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells. Mol Cancer Res. 2014;12:1166-80 pubmed publisher

product information

brand :

Tocris

master code :

3993

SKU :

3993/1

product name :

EB 1089

description :

Vitamin D receptor (VDR) agonist

target :

VDR-like Receptor Agonists

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

454.68

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Vitamin D receptor (VDR) agonist; analog of calcitriol (Cat. No. 2551). Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro ; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP).

catalog number base :

3993

product keywords :

EB1089 VDR agonist Vitamin D receptors seocalcitol VDR-like Seocalcitol Vitamin D Receptors Autophagy 3993,

extended description :

Vitamin D receptor (VDR) agonist

chemical name text :

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7 -methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol

formula :

C 30 H 46 O 3

formula text :

C30H46O3

cas num :

134404-52-7

2020 USD :

205

2021 USD :

212 USD

alt names :

Seocalcitol

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage