product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
AMTB hydrochloride
catalog :
3989
quantity :
10 mg (also 50 mg)
price :
227 USD
more info or order :
citations: 6
Reference
Diver M, Cheng Y, Julius D. Structural insights into TRPM8 inhibition and desensitization. Science. 2019;365:1434-1440 pubmed publisher
Morgan K, Sadofsky L, Morice A. Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep. 2015;35: pubmed publisher
Melikov K, Hara A, Yamoah K, Zaitseva E, Zaitsev E, Chernomordik L. Efficient entry of cell-penetrating peptide nona-arginine into adherent cells involves a transient increase in intracellular calcium. Biochem J. 2015;471:221-30 pubmed publisher
Mueller Tribbensee S, Karna M, Khalil M, Neurath M, Reeh P, Engel M. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. PLoS ONE. 2015;10:e0128242 pubmed publisher
Sałat K, Filipek B. Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. J Zhejiang Univ Sci B. 2015;16:167-78 pubmed publisher
Liu B, Lin Y, Lee H, Ho C, Ruan T, Kou Y. Menthol suppresses laryngeal C-fiber hypersensitivity to cigarette smoke in a rat model of gastroesophageal reflux disease: the role of TRPM8. J Appl Physiol (1985). 2015;118:635-45 pubmed publisher
product information
brand :
Tocris
master code :
3989
SKU :
3989/10
product name :
AMTB hydrochloride
description :
TRPM8 blocker
target :
TRPM Blockers
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
430.99
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
TRPM8 channel blocker. Inhibits icilin -induced TRPM8 channel activation in a rat model (pIC50 = 6.23).
catalog number base :
3989
product keywords :
TRPM8 transient receptor potential channels blockers TRPM 3989,
extended description :
TRPM8 blocker
chemical name text :
N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamide hydrochloride
formula :
C 23 H 26 N 2 O 2 S.HCl
formula text :
C23H26N2O2S.HCl
cas num :
926023-82-7
2020 USD :
218
2021 USD :
227 USD
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK