product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
AMTB hydrochloride
catalog :
3989/10
quantity :
10 mg (also 50 mg)
price :
292 USD
more info or order :
citations: 7
Reference
Diver M, Cheng Y, Julius D. Structural insights into TRPM8 inhibition and desensitization. Science. 2019;365:1434-1440 pubmed publisher
Spencer K, Belgacem Y, Visina O, Shim S, Genus H, Borodinsky L. Growth at Cold Temperature Increases the Number of Motor Neurons to Optimize Locomotor Function. Curr Biol. 2019;29:1787-1799.e5 pubmed publisher
Morgan K, Sadofsky L, Morice A. Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep. 2015;35: pubmed publisher
Melikov K, Hara A, Yamoah K, Zaitseva E, Zaitsev E, Chernomordik L. Efficient entry of cell-penetrating peptide nona-arginine into adherent cells involves a transient increase in intracellular calcium. Biochem J. 2015;471:221-30 pubmed publisher
Mueller Tribbensee S, Karna M, Khalil M, Neurath M, Reeh P, Engel M. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. PLoS ONE. 2015;10:e0128242 pubmed publisher
Sałat K, Filipek B. Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. J Zhejiang Univ Sci B. 2015;16:167-78 pubmed publisher
Liu B, Lin Y, Lee H, Ho C, Ruan T, Kou Y. Menthol suppresses laryngeal C-fiber hypersensitivity to cigarette smoke in a rat model of gastroesophageal reflux disease: the role of TRPM8. J Appl Physiol (1985). 2015;118:635-45 pubmed publisher
image
image 1 :
Tocris Bioscience 3989/10 image 1
Cat.No. 3989 - AMTB hydrochloride C23H26N2O2S.HCl CAS No. 926023-82-7
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3989
SKU :
3989/10
product name :
AMTB hydrochloride
description :
TRPM8 blocker
target :
TRPM Blockers
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Desiccate at RT
observed molecular weight :
430.99
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
AMTB hydrochloride is a TRPM8 channel blocker. Inhibits icilin -induced TRPM8 channel activation in a rat model (pIC50 = 6.23).
product keywords :
TRPM8 transient receptor potential channels blockers TRPM 3989,
extended description :
TRPM8 blocker
chemical name text :
N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamide hydrochloride
formula :
C23H26N2O2S.HCl
formula text :
C23H26N2O2S.HCl
cas num :
926023-82-7
USD :
283
USD 2025 :
292 USD
product details :
TRPM8 blocker
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK